Plaquenil is used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America, and Southern Asia. What if plaquenil doesn t work Chloroquine dose during pregnancy Do you still have flare ups while taking hydroxychloroquine Now it is generally used for rheumatoid arthritis, but it has also been shown to work well for juvenile arthritis, some lupus symptoms, and other types of autoimmune conditions. While doctors are not clear why this medication is effective for autoimmune conditions, the theory is that it interferes with the metabolic communication between the bodies immune system cells. Lupus-- also called systemic lupus erythematosus, or SLE -- might not have a cure, but it's a highly treatable condition. Lupus medications can help lower long-term risks and keep symptoms under. Lupus and Plaquenil research. While Plaquenil was not created with the explicit purpose of helping people minimize the disease activity of lupus, a number of clinical trials have been conducted to examine the clinical impact of the medication. Plaquenil is also an antirheumatic medicine and is used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. This medicine is not effective against all strains of malaria. Plaquenil not working anymore for lupus R/lupus - Anyone not going to work tomorrow with what’s., Lupus Medications and Treatments Prophylaxis for chloroquine resistant malariaObgyn plaquenil lupus indianaHydroxychloroquine screening testPlaquenil and eye twitchingPlaquenil eye effects Mar 24, 2011 What next if plaquenil doesn't work. I wish the plaquenil was working but it's not. I feel so bad every day. I don't even know anymore. I have been on it for. What next if plaquenil doesn't work?. Plaquenil Hydroxychloroquine for Lupus - LupusCorner. When was plaquenil not enough anymore? lupus. Unfortunately, retinal damage caused by Aralen may be irreversible, but this medication is rarely prescribed anymore for lupus. Do not smoke while taking anti-malarial medications, since smoking actually reduces the benefits of these drugs. In fact, people with lupus should not smoke at all due to their increased risk of cardiovascular disease. Dooley says time of day also matters less with Plaquenil® hydroxychloroquine. But, it’s best taken with food. Non-steroidal anti-inflammatories like ibuprofen and naproxen can give people heartburn or upset stomach, she says, so take them at least two hours before you lie down at night or with medications that protect your stomach. It could be that it is not the best NSAID for you. Ibuprofen didn't suit me at all, it actually made my joint and muscles swell, probably some kind of sensitivity to it, some others with Lupus report this. It would be worth trying another NSAID, preferably one that has a long term action throughout the day and it may well solve a lot of this.