One such commonly used medication for dermatologic and rheumatologic inflammatory conditions is hydroxychloroquine (Plaquenil), a chloroquine derivative. It is used to treat many diseases including malaria, rheumatoid arthritis and systemic lupus erythematosus. Plaquenil macular toxicity oct Plaquenil rash side effects Aug 26, 2016 Hello, I was recently told by my internal medicine doctor, after years of cataloging symptoms, that she was going to begin treating me for Lupus. She started me on the generic version of Plaquenil at 200 mg. I have had a really hard time on this medicine. I have had extreme nausea, diarrhea, stomach cramps, and intense vertigo. I began taking it on Thanksgiving day and still experience these. Jun 19, 2015 Brief Answer plaquenil toxicity Detailed Answer My dear, Thanks for sending your query to us. These drugs do have a toxicity but it is reason doctors are worried is that once toxicity occures,it continues even after stopping the drug. Otherthan retinal examination,useful information. Common Plaquenil side effects may include headache, dizziness, ringing in your ears; nausea, vomiting, stomach pain; loss of appetite, weight loss; mood changes, feeling nervous or irritable; skin rash or itching; or. hair loss. It is imperative that patients and physicians are aware of and watch for this drug’s ocular side effects. Retinal toxicity from hydroxychloroquine is rare, but even if the medication is discontinued, vision loss may be irreversible and may continue to progress. Plaquenil toxicity signs and symptoms Plaquenil Risk Calculators, What are the symptoms of Plaquenil toxicity? Ufo sign plaquenilChloroquine kinase Funny I tried Plaquenil a few times in the past just to see if I could tolerate it and after one dose the ache started then too but I never had the other symptoms as I stopped it immediately. Now I feel I need it again so I persisted and the other symptoms popped up. No one seems to know what "pre" toxic symptoms might be. Hydroxychloroquine and eye symptoms. Plaquenil Uses, Dosage & Side Effects -. Plaquenil Side Effects on Your Eyes and Vision. Signs or symptoms of cardiac compromise have appeared during acute and chronic treatment. Clinical monitoring for signs and symptoms of cardiomyopathy is advised, including use of appropriate diagnostic tools eg, ECG to monitor patients for cardiomyopathy during Plaquenil therapy. Taking Hydroxychloroquine develop toxicity2 It’s rare for side effects to occur with Plaquenil if the medication is dosed properly Side effects Blurred vision, bull’s eye maculopathy, scotoma, vortex keratopathy, headache, accommodative dysfunction, whitening of eyelashes, phototoxicity3 In early cases of Plaquenil toxicity, an early indicator of damage is the appearance of a paracentral scotoma seen on automated visual field testing in the absence of fundus changes. 18 Each of the testing strategies can be used to detect early toxicity changes, but the presentation of the visual field effects will vary. Due to the central area.