Please review the following URL and make sure that it is spelled correctly. Plaquenil is the brand name for the prescription drug hydroxychloroquine. Chloroquine autophagy in vivo Plaquenil skin rash symptoms Hydroxychloroquine dose per kg Hydroxychloroquine Plaquenil is considered a disease-modifying anti-rheumatic drug DMARD. It can decrease the pain and swelling of arthritis. It may prevent joint damage and reduce the risk of long-term disability. Hydroxychloroquine is in a class of medications that was first used to prevent and treat malaria. Hydroxychloroquine is often prescribed as long-term therapy for many dermatologic indications, and it may have broader benefits e.g. preventing or improving thrombophilia associated with lupus erythematosus, neonatal lupus erythematosus, diabetes in rheumatoid arthritis and other connective tissue diseases, and as adjunctive therapy in some cancers. Plaquenil is also an antirheumatic medicine and is used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. Important information. Taking Plaquenil long-term or at high doses may cause irreversible damage to the retina of your eye. Malaria is spread by mosquitoes, which transmit the parasites that cause the infection, usually in tropical and subtropical parts of the world. It's used to treat and prevent malaria infection, and to reduce symptoms and progression of autoimmune diseases such as lupus, rheumatoid arthritis, and others. Long term use of plaquenil Coding Long-term Medications, How Safe Is Long-Term Hydroxychloroquine? Side effect plaquenil eyesFolic acid and hydroxychloroquine Long-term studies in animals have not been conducted to evaluate the carcinogenic potential of PLAQUENIL. The mutagenic potential of hydroxychloroquine was not evaluated. However, chloroquine has been shown to be a catalytic inhibitor of DNA repair enzymes topoisomerase II and to produce weak genotoxic effects through this mode of action. Plaquenil Hydroxychloroquine Uses, Dosage, Side Effects.. Plaquenil Uses, Dosage & Side Effects -. The Risk of Retinal Toxicity with Plaquenil. Long term studies have shown a high rate of termination of hydroxychloroquine treatment in patients with RA. Although it has been shown that discontinuation of treatment with hydroxychloroquine is associated with exacerbation of SLE, long term maintenance rates of treatment with hydroxychloroquine in patients with SLE have not been investigated. How to use Plaquenil. eye problems or muscle/nerve damage, especially if you take it for a long time. This medication is not recommended for long-term use in children. If a child. Taking hydroxychloroquine long-term or at high doses may cause irreversible damage to the retina of your eye. You should not use hydroxychloroquine if you are allergic to it.