It does not work against certain types of malaria (chloroquine-resistant). The United States Center for Disease Control provides updated guidelines and travel recommendations for the prevention and treatment of malaria in different parts of the world. Plaquenil history Plaquenil and juvenile arthritis blue fingers Plaquenil lower heart rate I think this rash is just starting, so I don't know if it will develope into hives or what. Could this be related to the plaquenil. I have had some weird hive like rashes in the past that I was not able to get biopsied for lupus, so I don't know if this could be the case or not. If you definitely cannot take the plaquenil, then you should speak with your rheumy about starting may make you start to feel better. There are other anti-malaria drugs on the market that your rheumy can put you on instead of the plaquenil. But, make sure the he/she is convinced that you are actually allergic to the plaquenil. I wouldn't restart the plaquenil with the rash you have, I would ask for the biopsy or to see a dermatologist. The other possibility is that your liver didn't process the med well, however it is the standard med to start treating Lupus with. I hope they get it under control soon. This medication is also used, usually with other medications, to treat certain auto-immune diseases (lupus, rheumatoid arthritis) when other medications have not worked or cannot be used. Discuss the most recent information with your doctor before traveling to areas where malaria occurs. How to treat plaquenil rash How is plaquenil hydroxychloroquine used to treat lupus?, Allergic reaction to plaquenil DailyStrength Plaquenil tremors A more severe rash affecting larger areas of the body may occur but is not common. If this type of rash occurs, other medications such as anti-histamines and steroids may be required to help with symptoms. Over time, hydroxychloroquine may uncommonly have an adverse effect on the retina that can lead to permanent visual damage if not picked up early. In order to protect the eyes, a baseline exam is recommended be- fore starting the drug if you are color blind, have prior retinal problems or. Ask the Expert Plaquenil and Sjögren’s. Allergic reaction to Plaquenil Lupus Forums at The Lupus.. Plaquenil Hydroxychloroquine - Side Effects, Dosage, Interactions - Drugs. Topical treatments are also a standard part of cutaneous lupus therapy. Topical corticosteroids, such as triamcinolone or clobetasol, are available in a variety of doses and forms including creams, ointments, lotions, sprays, and shampoos to treat cutaneous lupus lesions or rashes just about anywhere on the body. May 15, 2015 Plaquenil is a mainstay of treatment for inflammatory arthritis and skin symptoms. Image Credit Alice Day/In 1984, I wrote my first prescription for the antimalarial drug, hydroxychloroquine Plaquenil, for a 28-year-old woman with SLE. The adult dose of Plaquenil to treat an acute attack of malaria is an initial dose of 800 mg followed by 400 mg in six to eight hours and 400 mg for two more days. To treat lupus erythematosus, the average adult dose is 400 mg once or twice daily.