Pregnant women and chloroquine

Discussion in 'Canada Drug' started by Atomic Max, 25-Feb-2020.

  1. meni2006 Well-Known Member

    Pregnant women and chloroquine


    While the mechanism is poorly understood, pregnant women have a reduced immune response and therefore less effectively clear malaria infections. In addition, malaria parasites sequester and replicate in the placenta.

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    Chloroquine and mefloquine are the drugs of choice for pregnant women for destinations with chloroquine-sensitive and chloroquine-resistant malaria, respectively. Doxycycline is contraindicated because of teratogenic effects on the fetus after the fourth month of pregnancy. However, if travel is unavoidable, pregnant women should take precautions to avoid mosquito bites, and use of an effective prophylactic regimen is essential. Chloroquine and mefloquine are the drugs of choice for pregnant women for destinations with chloroquine-sensitive and chloroquine-resistant malaria, respectively. Pregnant women are especially susceptible to malaria infection. Without existing immunity, severe malaria can develop requiring emergency treatment, and pregnancy loss is common. In semi-immune women, consequences of malaria for the mother include anaemia while stillbirth, premature delivery and foetal growth restriction affect the developing foetus.

    Malaria infection during pregnancy can lead to miscarriage, premature delivery, low birth weight, congenital infection, and/or perinatal death. Pregnant women are three times more likely to develop severe disease than non-pregnant women acquiring infections from the same area.

    Pregnant women and chloroquine

    Antimalarial drugs and pregnancy safety, pharmacokinetics., Pregnant Travelers - Chapter 7 - 2020 Yellow Book Travelers.

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  7. Chloroquine has not been formally assigned to a pregnancy category by the FDA. There are no controlled data in human pregnancies. Congenital anomalies were reported in the offspring of one woman being treated with chloroquine 250 to 500 mg daily during pregnancy for SLE; however, chloroquine has been used in the prophylaxis and treatment of malaria during pregnancy without evidence of fetal harm.

    • Chloroquine Use During Pregnancy.
    • Management of malaria in pregnancy.
    • FDA Urged to Approve Chloroquine to Treat COVID-19.

    Hydroxychloroquine Plaquenil and prednisone are considered safe during pregnancy. Methotrexate and cyclophosphamide Cytoxan should not be used in pregnancy and should be discontinued for at. Chloroquine, mefloquine are safe in pregnancy, doxycycline is not. While chemoprophylaxis in pregnancy appears efficacious, a major question remains—which agents are safest for both the woman and fetus? Some drugs routinely used in nonpregnant individuals should not be offered to pregnant women because of known direct effects on the fetus. Abnormalities 10 - 11. Women on cloroquine therapy should be converted to hydroxychloroquine with adequate time several months before conception to avoid fetal exposure 12. In conclusion the overriding message for clinicians involved in the care of pregnant women with SLE is that close monitoring of maternal disease activity and fetal

     
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  9. Beaver Well-Known Member

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  11. Henry91 User

    Chloroquine C18H26ClN3 - PubChem The mechanism behind the plasmodicidal action of chloroquine is not completely certain. Like other quinoline derivatives, it is thought to inhibit the heme polymerase activity, resulting in an accumulation of free heme, which is toxic to the parasites.

    Chloroquine mechanism of drug action and resistance in.