It does not work against certain types of malaria (chloroquine-resistant). The United States Center for Disease Control provides updated guidelines and travel recommendations for the prevention and treatment of malaria in different parts of the world. Hydroxychloroquine 200 mg tab tablet Chloroquine po 300 mg daily prophylaxis Dec 15, 2010 hello hope everyone is well just a quick question, i have been on methotrexate for 2 months increasing from 7.5 to 15 and now to 25mg.weekly now been given plaquenil 400mg daily, has anyone else been on this mixture and has it worked or how long should i wait to see if it works. I was on both medis for 15 years for mixed connective disease. I recently stopped methotrexate due to lungs involvement, my pulmonologist decided to put me on cellcept.i had no majors side effects but a metal taste when I first started. Make sure you have a chest X-ray yearly and periodic labs work. Good luck. The effects of methotrexate and hydroxychloroquine combination therapy vs. Laura A H A Gevers, Annelies E van Ede, Alfons A den Broeder, The effects of methotrexate and hydroxychloroquine combination therapy vs methotrexate monotherapy in. Folic acid 10 mg/week is standard-prescribed to minimize MTX side effects. At start of treatment. This medication is also used, usually with other medications, to treat certain auto-immune diseases (lupus, rheumatoid arthritis) when other medications have not worked or cannot be used. Discuss the most recent information with your doctor before traveling to areas where malaria occurs. Side effects of plaquenil and methotrexate Plaquenil Oral Uses, Side Effects, Interactions, Pictures., Methotrexate and plaquenil - @Kristinsaba1988. Folic acid and hydroxychloroquineHydroxychloroquine can suppress appetiteChloroquine and proguanil price I do know that plaquenil is generally considered the least invasive drug, generally prescribed as the first line of treatment. Methotrexate is the most commonly prescribed DMARD, but it does come with the chance of side-effects. I never had any side-effects of dire consequence, but many on this forum have. Methotrexate or Plaquenil? DailyStrength. Effects of methotrexate and hydroxychloroquine combination.. Common and Rare Side Effects for Methotrexate Anti-Rheumatic.. This study is created by eHealthMe based on reports of 23,242 people who take Methotrexate and Plaquenil from Food and Drug Administration FDA, and is updated regularly. On eHealthMe, you can evaluate side effects and drug interactions from 15 million FDA reports. Side Effects Nausea, stomach cramps, loss of appetite, diarrhea, dizziness, or headache may occur. If any of these effects persist or worsen, notify your doctor or pharmacist promptly. Remember. Serious side effects. blurred vision or other vision changes. ringing in your ears or hearing loss. angioedema, or rapid swelling of your skin. hives. mild or severe bronchospasm that causes trouble breathing. sore throat. unusual bleeding or bruising. blue-black skin color. muscle weakness. hair.