Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. How long do you need to use plaquenil How much plaquenil medication cost A large medical specialty society for ophthalmologists recently updated its recommendations for the screening of chloroquine CQ and hydroxychloroquine HCQ retinopathy.1 You Might Also Like Hydroxychloroquine Retinopathy Still Alive and Well Ocular Disease Monitoring Critical to Avoid Retinal Toxicity from Hydroxychloroquine Rheumatologists Debate Hydroxychloroquine Dosing Guidelines for. If you are taking Plaquenil to treat an inflammatory condition or malaria, you should be aware of the side effects that may occur to your eyes and vision. Plaquenil hydroxychloroquine is in a class of drugs called disease-modifying anti-rheumatic drugs, which are used to decrease inflammation, pain and joint damage. Because HCQ is cleared by the kidneys, renal disease raises the risk of toxicity, and both dosage and screening frequency may need to be adjusted in these patients.2. Tamoxifen use. Concomitant use of HCQ and tamoxifen, which is prescribed to treat and prevent breast cancer, raises the risk of HCQ toxicity approximately 5-fold. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Omphthamologists risks of hydroxychloroquine Drug spotlight on hydroxychloroquine Lupus Foundation of., Plaquenil Side Effects on Your Eyes and Vision Retinal thickness map plaquenil toxicity While side effects of corticosteroids are usually to blame, there is also the possibility of ocular damage associated with long-term use of the antimalarial drugs hydroxychloroquine brand name Plaquenil® and chloroquine. Improved vision screening tests and updated dosing guidelines are key to avoiding such complications. Protecting your eyesight when taking Plaquenil Lupus.. Plaquenil Guidelines Point Out New Risks, New Presentation.. Hydroxychloroquine - Royal College of Ophthalmologists. Doses ≥ 5 mg/kg/day real weight of hydroxychloroquine 2.3 mg/kg/day of chloroquine are associated with higher risk of toxicity. Doses lower than 5 mg/kg/day have low risk 1% for the first 5 years, and below 2% between 5-10 years of use. To determine the prevalence of high-risk factors for hydroxychloroquine HCQ retinopathy and compliance with the American Academy of Ophthalmology AAO screening guidelines at the San Francisco Veterans Affairs Medical Center VASF and to develop an approach to improve the risk-benefit relationship and informed consent during HCQ treatment. Hydroxychloroquine is a well tolerated medication for various rheumatologic and dermatologic conditions. Its main side effects are gastrointestinal upset, skin rash, headache, and ocular toxicity. Within the eye, hydroxychloroquine negatively impacts the cornea, ciliary body, and retina.