One such commonly used medication for dermatologic and rheumatologic inflammatory conditions is hydroxychloroquine (Plaquenil), a chloroquine derivative. It is used to treat many diseases including malaria, rheumatoid arthritis and systemic lupus erythematosus. Pharmacokinetics of chloroquine phosphate Chloroquine hydroxychloroquine Diagnosis Hydroxychloroquine-induced retinal toxicity Discussion. Chloroquine CQ and hydroxychloroquine Plaquenil HCQ have been used for many years, initially for the treatment of malaria but now more commonly for the treatment of inflammatory diseases such as rheumatoid arthritis and lupus 1. Note This document contains side effect information about hydroxychloroquine. Some of the dosage forms listed on this page may not apply to the brand name Plaquenil. For the Consumer. Applies to hydroxychloroquine oral tablet. Along with its needed effects, hydroxychloroquine the active ingredient contained in Plaquenil may cause some unwanted effects. FAF is an objective imaging test that uses the properties of the RPE to detect early toxicity. In early hydroxychloroquine toxicity, FAF often shows subtle parafoveal hyperautofluorescence, thought to be related to increased lipofuscin activity in the RPE. 4 In later stages of disease, hypoautofluorescence will be noted and is an indication of. It is imperative that patients and physicians are aware of and watch for this drug’s ocular side effects. Retinal toxicity from hydroxychloroquine is rare, but even if the medication is discontinued, vision loss may be irreversible and may continue to progress. Serious toxicity of hydroxychloroquin Hydroxychloroquine Plaquenil Side Effects & Dosage for., Plaquenil Side Effects Common, Severe, Long Term - Guidelines for plaquenil screeningMoa chloroquine malariaPlaquenil and mmr vaccine Patients may notice paracentral scotomata with early toxicity, but toxicity may progress despite discontinuation of the drug, and can lead to more serious loss of central and peripheral vision, for which there is no known treatment. Thus, screening for the earliest signs of retinal toxicity has been the core of “management” for the condition. Rates and predictors of hydroxychloroquine retinal toxicity in patients.. Retina Today - Imaging in Hydroxychloroquine Toxicity April 2019. Plaquenil Toxicity - Symptoms, Treatment, Risk Factors.. Lyons emphasizes the importance of annual screening and says that, although annual screening is recommended for everyone taking Plaquenil, it is imperative for people who have been taking the medication for more than 10 years, who have a higher incidence of retinal toxicity. Plaquenil-induced toxicity usually will not occur before five years of. Side Effects. Drug information provided by IBM Micromedex Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Hydroxychloroquine is used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America.