Hydroxychloroquine is available as the brand-name drug Plaquenil. Generic drugs usually cost less than the brand-name version. Hydroxychloroquine may be used as part of a combination therapy. Maculopathy from plaquenil Methotrexate and plaquenil interaction What is the mode of action of chloroquine Hydroxychloroquine-mediated retinopathy Dr. Kim responded Nothing safer. Plaquenil is also known as hydroxychloroquine, so the parent drug Chloroquine can be substituted. But Chloroquine has significantly higher rate of retinal toxicity, so it isn't used much anymore. Nothing safer Plaquenil is also known as hydroxychloroquine, so the parent drug Chloroquine can be substituted. But Chloroquine has significantly higher rate of retinal toxicity, so it isn't used much anymore. Also, Plaquenil appears to effectively reduce flares in patients with lupus not necessarily by suppressing immunity. Rheumatoid arthritis is a chronic disorder for which there is no known cure. Fortunately in the last few years, a shift in strategy toward the earlier institution of disease modifying drugs and the availability of new classes of medications have greatly improved the outcomes that can be expected by most patients. Hydroxychloroquine is used to treat lupus erythematosus and rheumatoid arthritis. It isn’t fully understood how this drug works to treat lupus erythematosus or rheumatoid arthritis. That means you may need to take it with other drugs. It treats malaria by killing the parasites that cause the disease. Substitute for plaquenil What can substitute for plaquenil? Yahoo Answers, Plaquenil substitute - Things You Didn’t Know Plaquenil and liver toxicitySd oct plaquenilLichen planopilaris plaquenilDoes hydroxychloroquine cause eye problems Plaquenil rated 6.8/10 in overall patient satisfaction. Compare Plaquenil head-to-head with other drugs for uses, ratings, cost, side effects, interactions and more. Plaquenil Compared to Alternatives - Plaquenil Compared to Alternatives -. Rheumatoid Arthritis Treatment Options Johns Hopkins.. Discontinued Plaquenil.other options?. Substitutes and alternatives to Plaquenil hydroxychloroquine for uses like Rheumatoid arthritis, Lupus and Malaria Hydroxychloroquine Plaquenil is used to treat malaria, lupus, and rheumatoid arthritis. Learn about side effects, warnings, dosage, and more. This information is not a substitute for medical. Plaquenil hydroxychloroquine is commonly used to help keep mild lupus-related problems, such as skin and joint disease, under control. This drug is also effective at preventing lupus flares.