Pattern of Retinopathy: Although the locus of toxic damage is parafoveal in many eyes, Asian patients often show an extramacular pattern of damage. Dose: We recommend a maximum daily HCQ use of 5.0 mg/kg real weight, which correlates better with risk than ideal weight. Chloroquine stability in water Using pei vs chloroquine Plaquenil muscle pain Hydroxychloroquine and famotidine Take hydroxychloroquine with food or milk. Swallow whole. Do not chew, break, or crush. Keep taking hydroxychloroquine as you have been told by your doctor or other health care provider, even if you feel well. Do not take antacids or kaolin within 4 hours of hydroxychloroquine. What do I The usual adult dose for treating malaria is 800 mg initially, followed by 400 mg 6-8 hours later and then 400 mg at 24 hours and 48 hours. The dose for malaria prevention is 400 mg every week starting 1 or 2 weeks before exposure and for 4 weeks after leaving the high risk area. Since the initial screening and monitoring recommendations were published in 2002, there have been reports of retinal toxicity associated with the use of Plaquenil. Furthermore, the advent of novice sensitive diagnostic modalities has led to a revision of the recommended guidelines for patients using Plaquenil see “2011 Plaquenil Screening. Risk of Toxicity: The risk of toxicity is dependent on daily dose and duration of use. There are no similar demographic data for CQ, but dose comparisons in older literature suggest using 2.3 mg/kg real weight. Monitoring hydroxychloroquine Hydroxychloroquine DermNet NZ, Hydroxychloroquine Plaquenil Side Effects & Dosage for Malaria What if plaquenil doesn t workHydroxychloroquine side efects Individuals beginning HCQ therapy should be informed of the possibility, although extremely rare, of retinal toxicity, and told that periodic monitoring can lead to early recognition of some symptoms. Hydroxychloroquine is the most commonly used AM, specifically because it has a lower risk for retinal toxicity than chloroquine. Drug spotlight on hydroxychloroquine Lupus Foundation of.. New Plaquenil Guidelines. Hydroxychloroquine Oral Uses, Side Effects, Interactions.. DMARD MONITORING GUIDELINES – FOR GP INFORMATION Hydroxychloroquine A. Indications Licensed RA, connective tissue diseases systemic and discoid lupus and some photosensitive dermatological conditions B. Dose Grade of evidence C Typical regime 200–400 mg daily. Dosage may be reduced to 200 mg daily depending on clinical response. Monitoring and Preventing Hydroxychloroquine, Plaquenil, Toxicity. The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U. S. Federal Government. Read our disclaimer for details. The number of patients taking hydroxychloroquine is increasing and monitoring patients on therapy is challenging in the currently over stretched hospital eye service. A recent paper estimates.