It says on the bottle I can’t take an antacid for at least four hours after taking the Plaquenil. I hate heart burn:( I take a PPI (proton pump inhibitor) essentially antacid in the morning that is supposed to last all day. I would ask your pharmacist first and see if it matters whether it is just a 'tums' or medication strength. I think if it keeps happening I’ll go talk to my pharmacist to see what they recommend. Has anyone else experienced heartburn while taking Plaquenil and if so what did you do to avoid or ease the heartburn? If they are not able to give you an answer your Family Dr or Rheumatoid will know. Fortunately the heartburn goes away after a few hours, but those few hours are very uncomfortable! Immunosuppressant plaquenil Side effects from plaquenil on eye Plaquenil and cancer risk Hydroxychloroquine Plaquenil is considered a disease-modifying anti-rheumatic drug DMARD. It can decrease the pain and swelling of arthritis. It may prevent joint damage and reduce the risk of long-term disability. Hydroxychloroquine is in a class of medications that was first used to prevent and treat malaria. Hydroxychloroquine Major Hydroxychloroquine absorption may be reduced by antacids as has been observed with the structurally similar chloroquine. Administer hydroxychloroquine and antacids at least 4 hours apart. Of note, a study demonstrated no significant difference in hydroxychloroquine serum concentration in patients taking concomitant. Section of the Plaquenil hydroxychloroquine drug label regarding cardiac effects, including cardiomyopathy and QT prolongation, and hypoglycemia. and for the prophylaxis of malaria in geographic areas where chloroquine resistance is not reported. But that's just the optimum way to take it, not the necessity. Sometimes what is suggested (no antacid for 4 hours) is not necessarily required if it means you can't or don't want to take your plaquenil anymore. the antacid will affect the absorption of the plaquenil and the amount your body can absorb. Hydroxychloroquine and antacids Hydroxychloroquine tablets - Cleveland Clinic, Aluminum Hydroxide aluminum hydroxide dose, indications. Byproduct of chloroquine synthesisDoes plaquenil cause you to gain weightChloroquine malaria dna binding theoryWhich is better for ra plaquenil or methotrexate Hi As far as I know the advice is to make sure that antacids and Plaquenil are taken at least 4 hours apart. If they are taken together - effectiveness decreases but 4 hours apart is OK. Plaquenil and antacids?. Plaquenil hydroxychloroquine – New Warnings. Drugs & Medications - WebMD. Hi Enjoy, You are right that only antacids react with plaquenil, not acid reducers, at least for the main ones that I checked on On which is one of our approved sites for linking in the forum, you can look up all your medications and the drug interaction listings are especially nice. Plaquenil and Pepcid. Support Forums. I wonder if this is a personal opinion about taking it earlier than the plaquenil or maybe something we need to check into more. Hi Gidget. It may be how the pepcid it works. Some of this stuff is an antacid and some is a proton pump inhibitor. I would listen to the pharmacist because they know more. Antacids Major Hydroxychloroquine absorption may be reduced by antacids as has been observed with the structurally similar chloroquine. Administer hydroxychloroquine and antacids at least 4 hours apart.