While these reviews might be helpful, they are not a substitute for the expertise, skill, knowledge and judgement of healthcare practitioners. "I was on this hydroxychloroquine for 6 months and then suddenly developed severe itching (burning like sensation, worse than any itch I have ever had) and rash that went from my neck to my feet. Act chloroquine and arte sunate Long term side effects of hydroxychloroquine What is the filler in hydroxychloroquine Do you have to be weaned off of plaquenil SIDE EFFECTS. The following adverse reactions have been identified during post-approval use of PLAQUENIL or other 4-aminoqunoline compounds. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure. Plaquenil hydroxychloroquine is a medication that has been used for many years to help musculoskeletal symptoms and fatigue in patients with autoimmune conditions such as rheumatoid arthritis, lupus and Sjögren’s. Plaquenil is prescribed for the treatment or prevention of malaria. It is also prescribed for the treatment of rheumatoid arthritis, lupus, and the side effects of lupus such as hair loss, joint pain, and more. I'm not completely pain free, but it's a lot better than it was. I've been on plaquenil since mid June I have had a lot of stress in my life so I can't determine what is causing what. Not seeing any improvements with pain but I just went to 0 prednisone 3 weeks ago. said give it a few months and if I don't see any improvement I might as well go off of it. Wanted to let you know that I was on plaquenil for about three years and I told my RA doctor that my fatigue was worse. Hi everyone, I am wondering if anyone has had a problem with fatigue while on Plaquenil. At first, I was nauseous for a week or so, which the dr. After the nausea went away it seemed like my pain got worse for a week or so, and then it gradually got better. I am also bothered with stomach cramps and mild diarrhea. How does plaquenil help with fatigue Hydroxychloroquine User Reviews for Sjogren's. -, Ask the Expert Plaquenil and Sjögren’s Hydroxychloroquine mechanism of action ra Dr. Krauser responded Yes. Fatigue is the result of the inflammation. If Plaquenil hydroxychloroquine works, it will also help the fatigue. Plaquenil hydroxychloroquine helps inflammation, will.. Hydroxychloroquine Plaquenil Side Effects & Dosage for.. Is extreme fatigue a side effect of Plaquenil?. Today, Plaquenil and other antimalarials are also used to treat and help prevent symptoms caused by certain autoimmune diseases such as rheumatoid arthritis RA, systemic lupus erythematosus, and discoid lupus, even though these diseases are not caused by malaria parasites. If experienced, these tend to have a Severe expression. Abnormal Liver Function Tests. Acute Liver Failure. Acute Pustular Eruptions On Skin. Bronchospasm. Decreased Blood Platelets. Decreased White Blood Cells. Deficiency Of Granulocytes A Type Of White Blood Cell. Plaquenil is a unique drug that helps control/suppress certain autoimmune symptoms. Plaquenil will not work for everyone with autoimmune issues. But there are other drugs like Erythromycin, Azithromycin, Doxycycline, Fluconazole, Malarone, ect. that may work better for your autoimmune condition.