Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Figuring hydroxychloroquine dossage Can you take diet pills with hydroxychloroquine Find patient medical information for Plaquenil Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Plaquenil has never raised my liver enzymes and I have been on it for six years. The only time my ALT and AST were elevated when I was taking too much iron supplements for my anemia. Once I stopped those, the enzymes went back to normal. Plaquenil can elevate liver enzymes too. Do you take any other medications? It can be a full month before you see liver enzymes start to retreat. Please, don't panic. I panicked enough for everyone and learned a LOT. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Plaquenil liver enzymes Arthritis Which would you pick and why? - Plaquenil or., Plaquenil and elevated liver enzymes? - Sjogren's World Swelling after stopping plaquenilChloroquine premaquin Liver enzymes are present in liver cells and are spilled out into the bloodstream when there is an injury or illness to the liver. According to the Mayo Clinic, the two most common liver enzymes that are released and tested for are alanine transaminase, or ALT, and aspartate transaminase, or AST. Rheumatoid Arthritis & Elevated Liver Enzymes Healthfully. Liver Enzyme increase DailyStrength. Plaquenil Warnings and Precautions. I to have been taking plaquenil for at least 6 to 8 months not sure a lil lupie lol anyway and i do feel a difference in my eyes plus my liver enzymes are up i believe that the highest is 47 and mines is 48 the doc says not dangerously high but we need to keep an eye on it. im not sure but i thought that the enzymes were up cuz of the prednisone but now ill have to ask the doc. i too want. I have recently started taking plaquenil foe RA. My doctor called and said their was a slight change in my liver numbers. He said it is nothing to worry about. I was wondering does plaquenil affect your liver? If any of you experienced this please let me know. Thank-you, JK May 18, 2018 High liver enzymes can be a result of lupus, and my rheumatologist said some of this is not uncommon in lupus patients. Although it is uncommon, lupus can also attack a patient’s liver, causing a more pronounced elevation in liver enzymes, such as ASTs and ALTs.