Why both chloroquine and primaquine

Discussion in 'Canadian Pharcharmy' started by Petyari, 05-Mar-2020.

  1. Leonboy New Member

    Why both chloroquine and primaquine


    Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it.

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    Starting from available precursors, we designed and synthesized a new-generation compound consisting of both primaquine and chloroquine components, with the intent to produce agents that exhibit bioactivity against different stages of the parasite's life cycle. Primaquine phosphate is recommended only for the radical cure of vivax malaria, the prevention of relapse in vivax malaria, or following the termination of chloroquine phosphate suppressive therapy in an area where vivax malaria is endemic. Patients suffering from an attack of vivax Oct 15, 2018 For effective radical cure, primaquine must be used in full dose as per body weight for 14 days. Although most recommendations, including the NVBDCP-India, suggest a dose of 0.25mg/kg/day, at an average of 15mg/day, for 14 days, it may not be effective in some, particulalry those with a much higher body weight.

    The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead.

    Why both chloroquine and primaquine

    Medicines for the Prevention of Malaria While Traveling., PRIMAQUINE

  2. Wikipedia hydroxychloroquine
  3. Primaquine should not be administered to anyone with G6PD deficiency because a severe reaction can occur, resulting in hemolytic anemia. However, the WHO has recommended that a single dose of primaquine 0.25 mg/kg is safe to give even in individuals with G6PD deficiency, for the purpose of preventing transmission of P. falciparum malaria.

    • Primaquine - Wikipedia.
    • Primaquine – Malaria Site.
    • Pharmacokinetic Interactions between Primaquine and Chloroquine.

    Primaquine phosphate is an 8-amino-quinoline compound which eliminates tissue exoerythrocytic infection. Thereby, it prevents the development of the blood erythrocytic forms of the parasite which are responsible for relapses in vivax malaria. Primaquine phosphate is also active against gametocytes of Plasmodium falciparum. INDICATIONS AND USAGE Both the treatment arms offer evidence of good tolerability and efficacy. In other previous study performed in an area with high chloroquine-resistance Southern Papua, Indonesia, DHA-PQP was compared to ASAQ, but never compared to chloroquine by itself in areas where chloroquine still works. Verapamil, a Ca 2+ channel blocker, has been found to restore both the chloroquine concentration ability and sensitivity to this drug. Recently, an altered chloroquine-transporter protein CG2 of the parasite has been related to chloroquine resistance, but other mechanisms of resistance also appear to be involved.

     
  4. DragonV User

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  5. ashotius New Member

    rimaquine is the essential co-drug with chloroquine in treating all cases of malaria. LIDOCAINE OINTMENT USP, 5% Side Effects of Chloroquine and Primaquine and Symptom Reduction in. Pharmacokinetic Interactions between Primaquine and Chloroquine
     
  6. samurai Well-Known Member

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