Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Hydroxychloroquine treatment of rheumatoid arthritis Chloroquine phosphate reef tank Tests to get before starting hydroxychloroquine The Risk of Retinal Toxicity with Plaquenil Posted on Fri, Aug 29, 2014 Plaquenil, hydroxychloroquine HCQ, is an anti-malarial medication that has been proven to be useful in the treatment of patients with rheumatoid arthritis RA, systemic lupus erythematosus SLE and other inflammatory and autoimmune diseases. Retinal toxicity from hydroxychloroquine use cannot be completely prevented, but effective screening should recognize retinal toxicity before symptoms or significant risk of central vision loss appear ie, before the appearance of bull’s eye maculopathy. To reduce the incidence of chloroquine and hydroxychloroquine toxicity, health care providers HCP's that prescribe these medications and those that screen for ocular toxicity have developed clear dosing and screening protocols that have reduced the risk of end-stage disease; bull's eye maculopathy and central vision loss Level I. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Ocular toxicity hydroxychloroquine Systemic Drugs with Ocular Side Effects, Plaquenil Risk Calculators Tumors associated with plaquenilPlaquenil dose for sjogrensPlaquenil cost at walmart Ocular side effects of hydroxychloroquine can include impact on the cornea, ciliary body, lens and retina. 1 Corneal deposits, fortunately, rarely affect vison. 2 However, the concern of retinal toxicity and the need for monitoring must be reviewed with patients prior to and during its use. 2,3 Ocular Disease Monitoring Critical to Avoid Retinal Toxicity.. Chloroquine And Hydroxychloroquine Toxicity - Abstract.. Retinal toxicity associated with chronic exposure to.. One of the most serious side effects is a toxicity in the eye generally with chronic use. People taking 400 mg of hydroxychloroquine or less per day generally have a negligible risk of macular toxicity, whereas the risk begins to go up when a person takes the medication over 5 years or has a cumulative dose of more than 1000 grams. Hydroxychloroquine has been used since the 1950s for the treatment of various rheumatic and dermatologic diseases. Hydroxychloroquine can cause ocular toxicity, with the most serious being an irreversible retinopathy. At the present time, no "gold standard" exists for identification of the ocular toxicity prior to its development. Hydroxychloroquine is a well tolerated medication for various rheumatologic and dermatologic conditions. Its main side effects are gastrointestinal upset, skin rash, headache, and ocular toxicity. Within the eye, hydroxychloroquine negatively impacts the cornea, ciliary body, and retina.