Chloroquine is now uncommonly used in favor of its derivative hydroxychloroquine. In the United States, hydroxychloroquine is most often used for its anti-inflammatory effects in rheumatology and dermatology. Effects of ultraviolet ray on chloroquine Plaquenil and coumadin interaction What blood tests are required while on plaquenil Oct findings of plaquenil maculopathy Sometimes mistaken for a retina problem, ethambutol toxicity causes painless loss of central or paracentral vision when the drug damages the optic nerve, which can lead to an optic neuropathy that is symmetric and usually bilateral, said Dr. Shah. Other symptoms may include photophobia or poor dark adaptation. Testing. However, peripheral neuropathy may also be non-symmetrical or more sporadic, affecting patches of areas in the body. This can result from vasculitis, or inflammation of the blood vessels. Symptoms of Neuropathy in Lupus. Symptoms of peripheral neuropathy from lupus can range from mild to serious and mainly affect the hands, feet, legs or arms. Problems That Can Cause Optic Neuropathy Almost any underlying, chronic condition, injury, or toxin can lead to nerve damage in the eyes. It is important to know what your risks are, so if you begin to experience changes to your vision, you can visit your eye doctor immediately and discuss the potential causes of your vision issues. While early toxicity may be asymtomatic, patients with more advanced stage of toxicity may complain of color vision changes or paracentral scotomas. Its toxic effects on the retina are seen in the macula. Plaquenil and optic neuropathy Will you have Optic neuropathy with Hydroxychloroquine., Lupus and Nerve Damage Plaquenil charting Apr 15, 2018 Ethambutol is known to cause optic neuropathy characterized by bilateral central vision loss, color vision loss, central or cecocentral visual field scotomas and eventual optic atrophy. Know Your Systemic Meds The Top 10 to Track. Optic Neuropathy What Is It & Can You Reverse It? NVISION.. Plaquenil causes and treats neuropathy? - NeuroTalk Support.. Including our patient, there are 10 reported cases of HCQ neuromyotoxicity. Muscle biopsy consistently reveals curvilinear bodies and muscle fiber atrophy with vacuolar changes. Most cases manifest as insidious onset proximal myopathy that may be associated with peripheral neuropathy and cardiac myotoxicity. In the last two years, CARM has received two reports of ophthalmological reactions associated with hydroxychloroquine. Of the two reports, one report was of scotoma and one report was of retinal disorder. Retinopathy is a serious adverse reaction due to the progressive and irreversible nature of the changes. Toxic optic neuropathy TON refers to visual impairment due to optic nerve damage caused by a toxin. Toxic optic neuropathy is characterized by bilateral, usually symmetric vision loss, papillomacular bundle damage, central or cecocentral scotoma, and reduced color vision.