Even then we often have our symptoms treated long before they feel confident in making a Lupus diagnosis. all lupus type blood testing has came back negative as well two skin biopsies. People often have some intestinal issues when first starting plaquenil - things generally settle down in a few days. Also, it's good to have at least a few bites of food with it. It takes a rheumotologist to completely diagnose and treat Lupus. Hydroxychloroquine lower white blood cells Plaquenil and fatigue To get a Lupus diganosis you need to have 4 or more of 11 Lupus criteria, within a 5 year period. A lot of people have less than 4, or as in my case, more than 4 but spread out over much more than 5 years. So it's very possible for plaquenil to do good without you being considered to have Lupus. Changing diet for days beforehand then trying to keep down the liquid prep and stay near the loo and keep sane. Only once I managed to drink as much as the guide book says and didn't throw up more than about twice. Which in itself is a lesson - drink as much clear liquid as you possibly can. Lemonade is fine. Basically, plaquenil's effect is to modulate the immune system, which is something that could be quite beneficial for some of us. You can do what you want, but you might want to consider giving plaquenil more of a chance, and be far more wary of the prednisolone prednisone/steroid. Or, like Lynnwood said, a doctor may try us on a medication to see if our response to it is diagnostically useful. I have sun induced rashes and painful hip joints and burning in the very low back area. Also, is intestinal distress a side effect of plaquenil?? What can plaquenil do to you if taken wrong Foods to Avoid When Taking Plaquenil Oral, Gastroscopy, have to stop medication 10 days before? - UK. Hydroxychloroquine do not crush Please don't stop your plaquenil until you are sure it is the right thing to do and in your best interest. I am on plaquenil but also experience some of the same things you do. There are other meds that can help with what you are experiencing, and if your doctor didn't address that then I would seek out a second opinion. or maybe another. What is the correct way to discontinue use of plaquenil?. Plaquenil pros and cons - Sclero Forums MAIN - Sclero Forums. Plaquenil Indications, Side Effects, Warnings -. So you'd be hitting two or three things at once with a doxy/plaquenil combination. Plaquenil is also pretty well tolerated by most people. Maybe the worst symptom I had until I had to stop due to visual disturbances – rare! was some gastrointestinal discomfort, but it was tolerable, all in all, and I don't think everyone is affected that way. I've been on plaquenil for at least 15 years and from what i can remember it took about 6 months before i realized it was helping. now the best way to tell if its helping me is if i stop taking it, then i can REALLY tell. the pain is much worse along with the fatigue. plaquenil doesn't make it all go away but if i don't take it, it all comes. Yes, if the plaquenil controls your Lupus flares, it is best to not use the prednisone. I hope you can get off of it completely, or at least take a small maintenance dose. Take it very slow, tapering off, and if you have a reaction, severe fatigue, etc, talk to your doc, about tapering down even slower.