Chloroquine hydrochloride properties

Discussion in 'Canadian Pharmacy Drugs Online' started by AdrenalineTech, 29-Feb-2020.

  1. oLL XenForo Moderator

    Chloroquine hydrochloride properties


    Chloroquine is an anti-malaria medicine that works by interfering with the growth of parasites in the red blood cells of the human body. Parasites that cause malaria typically enter the body through the bite of a mosquito.

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    Chloroquine causes a toxic myopathy but also produces a toxic neuropathy. Chloroquine is an antimalarial drug also used for the treatment of severe rheumatoid arthritis, systemic lupus erythematosus, and other dermatological diseases. The clinical features of chloroquine-induced neuropathy are those of symmetrical sensorimotor polyneuropathy. Chloroquine hydrochloride 392.80 Chloroquine phosphate 515.87 Mechanism of action/Effect Antiprotozoal—Malaria Unknown, but may be based on ability of chloroquine to bind to and alter the properties of DNA. Chloroquine also is taken up into the acidic food vacuoles of the parasite in the erythrocyte. Co-administration of chloroquine and mefloquine may increase the risk of convulsions. The blood concentrations of chloroquine and desethylchloroquine the major metabolite of chloroquine, which also has antimalarial properties were negatively associated with log antibody titers.

    Chloroquine is used to treat and to prevent malaria. Malaria is common in areas such as Africa, South America, and Southern Asia.

    Chloroquine hydrochloride properties

    The relationship of physico-chemical properties and., Chloroquine Hydrochloride Drug Information, Professional

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  7. The place of chloroquine in current recommendations are dis-cussed on p.594. TREATMENT. In the treatment of patients with chloroquine-sensi-tive falciparum malaria studies have found chloroquine to be at least as effective as quinine in both uncomplicated and severe infections. However, very few areas exist where Plasmodium

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    Usual Adult Dose for Malaria Prophylaxis. 500 mg chloroquine phosphate 300 mg base orally on the same day each week Comments-If possible, suppressive therapy should start 2 weeks prior to exposure; if unable to start 2 weeks before exposure, an initial loading dose of 1 g chloroquine phosphate 600 mg base may be taken orally in 2 divided doses, 6 hours apart. Chloroquine is an anti-malaria medicine that works by interfering with the growth of parasites in the red blood cells of the human body. Parasites that cause malaria typically enter the body through the bite of a mosquito. The mode of action of chloroquine on plasmodia has not been fully elucidated. Chloroquine binds to and alters the properties of DNA. Chloroquine also binds to ferriprotoporphyrin IX and this leads to lysis of the plasmodial membrane. In suppressive treatment, chloroquine inhibits the erythrocytic stage of development of plasmodia.

     
  8. Aardvark Moderator

    The resource you are looking for (or one of its dependencies) could have been removed, had its name changed, or is temporarily unavailable. Hydroxychloroquine Side-effects, uses, time to work Hydroxychloroquine Sulfate Drug Information, Professional Hydroxychloroquine Oral Route Side Effects - Mayo Clinic
     
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    The development of resistance to drugs poses one of the greatest threats to malaria control and results in increased malaria morbidity and mortality. Chloroquine Mechanism of action and resistance in malaria 2. Efflux of chloroquine from Plasmodium falciparum. Effects of chloroquine on viral infections an old drug.
     
  10. Alex77 Guest

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