Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Plaquenil and neutropenia How much is chloroquine Plaquenil is generally well-tolerated, but side effects are possible. Common side effects linked to Plaquenil include nausea and diarrhea. Taking the medication with food eases nausea for most people taking the drug. Less common side effects include skin rashes, hair thinning, and weakness. Feb 19, 2020 Plaquenil hydroxychloroquine is an antimalarial medication used to treat or prevent malaria, a disease caused by parasites, which enter the body through the bite of a mosquito. Plaquenil is also used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. Chloroquine and hydroxychloroquine both belong to the quinolone family and share similar clinical indications and side effects, including retinal toxicity. Chloroquine-induced retinal toxicity was first described in 1959 and the retinal toxic effects of hydroxychloroquine were later described in 1967 3, 4. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Macular thinning and plaquenil Hydroxychloroquine Plaquenil Toxicity and., Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses Hydroxychloroquine side effects eyeHydroxychloroquine diabetesHydroxychloroquine grade c pregnancyHydroxychloroquine eye The retinal ganglion cells are densest in the macula and form a stratified multi-cellular layer within the central 6 degrees of visual field. Therefore, loss of axons and the corresponding soma in this location is likely to cause a thinning of the retinal ganglion cell layer. The Role of the Macula OCT Scan in. - PubMed Central PMC. Hydroxychloroquine Plaquenil Toxicity and Recommendations.. Plaquenil Uses, Dosage & Side Effects -. Sep 13, 2019 Some of the dosage forms listed on this page may not apply to the brand name Plaquenil. For the Consumer. Applies to hydroxychloroquine oral tablet. Along with its needed effects, hydroxychloroquine the active ingredient contained in Plaquenil may cause some unwanted effects. Although not all of these side effects may occur, if they do occur. Patients often ask if their medications affect the risk of vision loss from age-related macular degeneration AMD. One class of medications can lead to more severe vision loss in people with the wet form of the disease, and another class of drugs may have a beneficial effect. You can read more about this new type of retinal imaging procedure here. The take away is this if you are taking this medication, talk to your doctor about the use of Plaquenil in your particular circumstance, discuss the dose prescribed, and get your eyes checked for Plaquenil related retinal toxicity on a regular basis.