B, Brown pigmentation on the legs in another patient who had systemic lupus erythematosus associated with diffuse discoid lupus. The skin biopsy was performed on the brown area distant from discoid lesions. Plaquenil and thyroid Plaquenil history Side effects plaquenil forums Chloroquine phosphate injection dosage Rashes may occur in up to 10% of patients, most commonly morbilliform or psoriasiform. Note that adverse cutaneous reactions to hydroxychloroquine are reported to affect more than 30% of patients with dermatomyositis, compared to a lower risk of rash in patients with cutaneous lupus erythematosus. Background Hydroxychloroquine sulfate and other antimalarial drugs have been used successfully as adjunctive therapy for patients with cutaneous lesions of dermatomyositis over the past 20 years. An increased incidence of cutaneous reactions to hydroxychloroquine has been postulated to occur in patients with dermatomyositis. Aug 26, 2013 Yes. Hair bleaching, hair loss, skin pigmentation, rash and itching are recognized skin adverse reactions of plaquenil hydroxychloroquine. These reactions tend to be worse if a patient is taking other medications that have similar skin toxicity. Please consult a dermatologist to ensure skin lesions are not psoriatic because Plaquenil hydroxychloroquine use needs special precautions in. B, Presence of iron in the same areas of the dermis (Perls staining, original magnification ×100). Pub Med Google Scholar Crossref Morrison LK, Nordlund JJ, Heffernan MP. Pub Med Google Scholar Costedoat-Chalumeau N, Galicier L, Aumaître O, et al; Group PLUS. Google Scholar Costedoat-Chalumeau N, Amoura Z, Hulot JS, et al. Pub Med Google Scholar Crossref Costedoat-Chalumeau N, Leroux G, Piette J-C, Amoura Z. A, Interstitial and perivascular brown pigmented granules in the dermis (hematoxylin-eosin-safran staining, original magnification ×100). Hydroxychloroquine induced rash Identifying Drug-Induced Lupus - U. S. Pharmacist, Adverse Cutaneous Reactions to Hydroxychloroquine Are More. Plaquenil and liver toxicityPlaquenil sulfa allergyPlaquenil nombre genericoStructure activity relationship of chloroquine pptDoes plaquenil lower sed rate S ir, Hydroxychloroquine is widely used in the treatment of rheumatoid arthritis and systemic lupus erythematosus, with very few reported side‐report the case of a 65‐yr‐old woman who developed Stevens–Johnson syndrome 2 weeks after commencing treatment with hydroxychloroquine. Stevens–Johnson syndrome in association with hydroxychloroquine.. Plaquenil hydroxychloroquine 200mg is it causing itchy skin.. Hydroxychloroquine-Induced Retinal Toxicity - American.. Cutaneous adverse reactions to hydroxychloroquine have been described, including acute generalized exanthematous pustulosis 11, 12, Stevens-Johnson syndrome 13, and toxic epidermal necrolysis 14–16. Here we report a case of hydroxychloroquine-induced erythema multiforme after 12 days of exposure in a 25 year old woman with lupus. Hydroxychloroquine is an antimalarial drug that is also used in the treatment of various rheumatic diseases including systemic lupus erythematous SLE. Various adverse reactions include skin rash, diarrhea, nausea and retinopathy were reported 1. Hydroxychloroquine induced myopathy is a rare side effect and reported prevalence is up to 6.7% 2. It is a known adverse reaction to quinine; hydroxychloroquine, as a synthetic derivative of this parent compound, may also put patients at risk of this complication. However, reports of hydroxychloroquine‐induced TTP are extremely rare in the literature.