Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking chloroquine: Incidence not known Some side effects of chloroquine may occur that usually do not need medical attention. Plaquenil liver toxicity Plaquenil and depression and anxiety Stopping plaquenil beforesurgery Hydroxychloroquine, sold under the brand name Plaquenil Sanofi-Aventis, is an antimalarial drug that has gained widespread use in treating various autoimmune diseases, including systemic lupus erythematosus and rheumatoid arthritis. 1 By some estimates, more than 150,000 patients are on long-term therapy with this medication in America alone. 2 Retinal toxicity associated with HCQ use is. Retinal toxicity from chloroquine CQ and its analogue, hydroxychloroquine HCQ, has been recognized for many years. Chloroquine toxicity remains a problem in many parts of the world, but is seen less frequently in the United States where the drug largely has been replaced by HCQ. Chloroquine and hydroxychloroquine both belong to the quinolone family and share similar clinical indications and side effects, including retinal toxicity. Chloroquine-induced retinal toxicity was first described in 1959 and the retinal toxic effects of hydroxychloroquine were later described in 1967 3, 4. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Chloroquine eye toxicity Chloroquine retinopathy - Wikipedia, Recommendations on Screening for Chloroquine and. Vision test for plaquenil Hydroxychloroquine sulfate HCQ, Plaquenil is an analogue of chloroquine CQ, an antimalarial agent, used for the treatment of systemic lupus erythematosus, rheumatoid arthritis and other autoimmune disorders. Its use has been associated with severe retinal toxicity, requiring a discontinuation of therapy. Retinal toxicity associated with chronic exposure to.. Hydroxychloroquine Plaquenil Toxicity and.. Hydroxychloroquine Plaquenil Toxicity and Recommendations.. Apr 02, 2019 However, a very close eye needs to be kept on this child as life-threatening toxicity may evolve rapidly. It is prudent to intubate a patient with a potentially significant chloroquine overdose if there is any significant depression of consciousness level or cardiovascular instability. Jul 30, 2019 The usefulness of hypokalemia as an indicator in the evaluation of chloroquine toxicity was studied in a retrospective series of 191 acute chloroquine poisonings. Results indicated that the risk of severe poisoning and death are proportional to the degree of hypokalemia. In view of the fact that all electron micro scopic studies on chloroquine toxicity in the eye have to date been limited to experimental animals, and because our experience has shown that tissues routinely fixed in Forma lin may occasionally be helpful in such stud ies,2 we decided to re-examine the material available from Wetterhold and Winter.