Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Can plaquenil lower blood pressure Plaquenil magnesium SIDE EFFECTS. The following adverse reactions have been identified during post-approval use of PLAQUENIL or other 4-aminoqunoline compounds. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure. Since the side effect of vision loss is possible but rare, it is important for you to tell your doctor about any vision changes that you experience. Doctors generally recommend regular eye exams while on Plaquenil, so that early changes can be caught. Once abnormalities are discovered, toxicity has already occurred. Plaquenil is the brand name of hydroxychloroquine, a drug used to prevent or treat malaria 2. Plaquenil is also used for long-term treatment of autoimmune diseases such as rheumatoid arthritis RA and systemic lupus erythmatosis. According to the Mayo Clinic, it can take up to six months' constant use before an effect is seen in RA 1. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. How can plaquenil affect your eyes Lupus Medicines Hydroxychloroquine - Brigham and Women's., Taking Plaquenil for Rheumatoid Arthritis Is chloroquine related to malarone Find patient medical information for Plaquenil Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Plaquenil Oral Uses, Side Effects, Interactions, Pictures.. Long-Term Side Effects of Plaquenil for Rheumatoid.. Will hydroxychloroquine hurt my eyes? - RheumDoctor. Plaquenil is usually used for long term disease control, rather than in the short term to control active bursts of inflammation. Plaquenil has important but uncommon side effects that may affect your eye. How does Plaquenil affect your eyes? PLAQUENIL hydroxychloroquine and the Eye. Download PDFVarious medications can affect the eyes and their drugs can be taken without damaging or changing the eyes in any way. However, a few systemic medications can cause damage to the eyes with subsequent vision changes. I think you need to discuss this issue with your RD. Let him or her know you want some control, but not to make your immune system go permanently insane. I do think that Plaquenil is the mildest drug you can find. I think they all get stronger and more immune-suppressant from there, but I might be wrong!