Those with APS make abnormal proteins called antiphospholipid autoantibodies in the blood. This causes blood to flow improperly and can lead to dangerous clotting in arteries and veins, problems for a developing fetus and pregnancy miscarriage. Hydroxychloroquine and prednisone in pregnancy Plaquenil-tablets uses Patients with antiphospholipid syndrome APS may be evaluated in an outpatient setting. Inpatient evaluation is required if the patient presents with a significant clinical event. Patients with CAPS require intense observation and treatment, often in an intensive care unit. A Catalyst for Antiphospholipid Syndrome Research Rheumatology Research Foundation The Foundation is the largest private funding source for rheumatology research and training in the U. S. Objectives To evaluate the impact of HCQ on aPL titers, on glucose and cholesterol levels and its role in the prevention of thrombotic recurrences in Primary Antiphospholipid Syndrome PAPS. Methods Patients with PAPS, diagnosed according to 2006 Classification Criteria without any Connective Tissue Disease. APS affects women five times more commonly than men. People with this disorder may otherwise be healthy, or they also may suffer from an underlying disease, most frequently systemic lupus erythematosus (commonly called lupus or SLE). Plaquenil for antiphospholipid syndrome Long-term use of hydroxychloroquine reduces., Is Hydroxychloroquine Helpful for Patients with. Chloroquine suppliedDoes plaquenil help with scarring alopeciaPlaquenil sarcoidosis treatmentRash as a side effect of plaquenilPlaquenil tablets hydroxychloroquine sulphate For patients with systemic lupus erythematosus who also have antiphospholipid syndrome, hydroxychloroquine Plaquenil has been reported to add some protection against blood clotting. Other reported treatments include the use of intravenous gamma globulin for selected patients with histories of premature miscarriage and those with low blood-clotting elements platelets during pregnancy. Antiphospholipid Syndrome Symptoms and Pregnancy Concerns. THU0289 Long Term Use of Hydroxychloroquine in Patients with.. Plaquenil and Antiphospholipid Syndrome - Reviews. Hydroxychloroquine is not currently used to treat patients with antiphospholipid syndrome APS. But new research in APS-induced mice shows hydroxychloroquine may improve endothelium-dependent dilation and reduce reactive oxygen species generation. Hydroxychloroquine for the First Thrombosis Prevention in Antiphospholipid Antibody Positive Patients The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Hydroxychloroquine Plaquenil is considered a disease-modifying anti-rheumatic drug DMARD. It can decrease the pain and swelling of arthritis. It may prevent joint damage and reduce the risk of long-term disability. Hydroxychloroquine is in a class of medications that was first used to prevent and treat malaria.