It's used to treat and prevent malaria infection, and to reduce symptoms and progression of autoimmune diseases such as lupus, rheumatoid arthritis, and others. Malaria is spread by mosquitoes, which transmit the parasites that cause the infection, usually in tropical and subtropical parts of the world. Plaquenil et prise de poids Hydroxychloroquine retinopathy cumulative dose Hi Everyone, I went to my Rheumatologist last week. She is giving me and my gastro. dr. a choice between Plaquenil and Methotrexate. One affects your eyes more and one affects your liver more. That is what my dr. said. So, what do yall know about the side effects of both and the benefits of both? I would appreciate any Renal failure and certain drug interactions such as interactions with tamoxifen, glycosides, methotrexate and ciclosporin can influence the pharmacokinetics of hydroxychloroquine and chloroquine. The use of nitrous oxide anesthesia with methotrexate is contraindicated see CONTRAINDICATIONS, WARNINGS AND PRECAUTIONS - Renal and DRUG INTERACTIONS - Drug-Drug Interactions Overview Methotrexate competes with reduced folates for active transport across cell membranes by means of a single carrier-mediated active transport process. For example, it may be combined with an antibiotic to treat chronic Q-fever, which humans usually catch from farm animals or raw milk. Plaquenil is used to treat other types of infections too. Interactions between plaquenil and methotrexate Does anyone take methotrexate and hydroxychloroquine. - NRAS, Mechanisms of action of hydroxychloroquine and chloroquine. 200 mg of plaquenil how long to workHair loss plaquenil myositisWho can do plaquenil eye exams Over the past few years, data have appeared that indicate a potential interaction between MTX and proton pump inhibitors PPIs. Evidence of an Interaction. The first case report of a potential interaction between MTX and a PPI was noted in a patient with osteosarcoma who was receiving high-dose 15 g MTX. Methotrexate and Proton Pump Inhibitors. METHOTREXATE methotrexate Drug Interactions Pfizer.. Hydroxychloroquine oral and methotrexate sodium oral Drug.. Methotrexate comes in four forms self-injectable solution, injectable IV solution, oral tablet, and oral solution. For the self-injectable solution, you can either receive it from a healthcare provider, or you or a caregiver can give it to you at home. Methotrexate self-injectable solution is used to treat psoriasis. I can't say for sure if plaquenil would slow down or halt progression of RA, but I've been told methotrexate does. As for a comparison between the two, it's difficult to say. As long as you have regular eye doctor appointments and blood tests to check for adverse reactions, you'd be able to catch anything bad ahead of time before significant. Plaquenil Interactions. Be extra careful about taking medicines that affect your blood cells or immune system, or that may be harmful to your liver when you are taking Plaquenil. Methotrexate.