Chloroquine is now uncommonly used in favor of its derivative hydroxychloroquine. In the United States, hydroxychloroquine is most often used for its anti-inflammatory effects in rheumatology and dermatology. Plaquenil hairline Plaquenil and diahreah Chloroquine in vitro concentrations Along with it comes thinning of the outer nuclear layer ONL, which is where the cell bodies of the photoreceptor cells reside. Vision loss from RP can also come from CME cystoid macular edema which is something to keep in mind for your RP patients. You can treat this with topical dorzolamide. Retinal detachment Parafoveal thinning of the outer nuclear layer follows, before retinal pigment epithelium damage is visible. Careful screening with multiple tests can detect toxic damage before prominent loss of the outer nuclear layer. Apr 16, 2010 Selective thinning of the perifoveal inner retina as an early sign of hydroxychloroquine retinal toxicity. inner nuclear layer INL, outer plexiform layer OPL, outer nuclear layer. While early toxicity may be asymtomatic, patients with more advanced stage of toxicity may complain of color vision changes or paracentral scotomas. Its toxic effects on the retina are seen in the macula. Plaquenil and thinning outer nuclear layer of retina Automated Segmentation Measurements of the Outer Nuclear., Comparison of Screening Procedures in Hydroxychloroquine Toxicity How long to see effects of plaquenilPlaquenil while pregnant risksAralen costoChloroquine mammalian cells Outer nuclear layer ONL thinning was present in 100 % and observed as a focal indentation in the parafoveal ONL when compared to peripheral ONL thickness. Disruption of the parafoveal interdigitation zone IZ was recorded in 88 % and reduced reflectivity of the parafoveal EZ band in the absence of definitive disruption was observed in 50 %. Expanded spectral domain-OCT findings in the early.. Selective thinning of the perifoveal inner retina as an early.. Neurosensory Retina. Conclusion HCQ toxicity resulted in significant outer retinal layer volumetric thinning compared with controls. Quantitative assessment of outer retinal parameters and EZ mapping on SD-OCT may become a useful biomarker to identify and monitor HCQ toxicity. The outer nuclear layer of FTD patients was about 10% thinner than controls, and this ONL thinning was the primary source of the outer retina thinning, the study added. Sep 15, 2012 By convention, the inner retina is close to the center of the eye—the vitreous—and the outer retina is close to the choroid and sclera. Remember that the outer retina contains the RPE and the photoreceptors, and the inner retina contains the retinal nerve fiber layer RNFL and the ganglion cells.