In many cases, once the offending drug has been stopped, fading of the lesions occurs. However, the pigmentation may last a long time or become permanent. Hydroxychloroquine monitoring Chloroquine and non-small cell lung cancer Plaquenil as it affects the eyes symptoms Hydroxychloroquine in pregnancy and lactation Aug 14, 2013 Hydroxychloroquine is an antimalarial medication that can cause hyperpigmentation of nails, mucosa, and skin 1–5. Retrospective studies cite the incidence of drug-related hyperpigmentation from hydroxychloroquine to be as high as 33% of individuals. Elder abuse is a cause of significant morbidity and mortality in older individuals 7–9. Description The authors illustrate the case of a woman in her 80s with history of systemic lupus erythematosus and Sjögren syndrome. She had lost medical follow-up with her rheumatologist in the last 3 years due to progressive functional and cognitive impairment but she was still taking prednisolone 5 mg per day and hydroxychloroquine 400 mg per day for, at least, the past 11 years. In 12 of 41 29% of the hydroxychloroquine users, we conclude a hydroxychloroquine-induced pigmentation. There were 11 women and one man with a mean age of 43 years and all of them were systemic. Download PDF Many systemic medications may cause retinal toxicity. Because many drugs that induce skin pigmentation also cause photosensitivity reactions, sun protection is usually recommended. Hydroxychloroquine induced pigmentation Hydroxychloroquine induced cutaneous pigmentation a unique pattern, Woman in grey hydroxychloroquine-induced hyperpigmentation. Hydroxychloroquine sulfate tablets 200mg400 mg plaquenil at nightPlaquenil and photophobiaHydroxychloroquine 200 mgtaPlaquenil and rash An elderly woman presented with 6 months history of skin coloured to erythematous papules in annular pattern over extremities, upper back and neck. The patient was diagnosed with granuloma annulare GA and started on hydroxychloroquine HCQ 300 mg daily. After 4 months of treatment, she developed bluish grey pigmentation within the plaques of GA with normal surrounding skin figure 1A,B. Hydroxychloroquine induced cutaneous pigmentation a unique.. Hydroxychloroquine-Induced Hyperpigmentation. Hydroxychloroquine-induced hyperpigmentation in systemic.. Some medications, such as plaquenil and minocycline, can cause permanent dark skin plaques, which resemble black and blue marks similar to morphea scleroderma. Cosmetically, pigmentation differences can be covered up with corrective cosmetics, such as Dermablend. Drug-Induced Hyperpigmentation caused by Minocycline Minocin Antibiotic Skin Hyperpigmentation with Hydroxychloroquine Hydroxychloroquine Plaquenil is a common trade name is an anti-inflammatory oral medication that is commonly used to treat many autoimmune diseases. In the hair clinic, we use it for diseases such as lichen planopilaris, frontal fibrosing alopecia, The incidence of hydroxychloroquine-related hyperpigmentation in patients with systemic lupus erythematosus is about 7%, but unlike hydroxychloroquine-related retinopathy, there is no clear association with cumulative dose or duration of use.1 Roughly half of cases occur in the first five years of treatment.