Synthesis of chloroquine phosphate

Discussion in 'Chloroquine' started by the_ghost, 22-Feb-2020.

  1. oleg9999 Moderator

    Synthesis of chloroquine phosphate


    Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it.

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    Chloroquine Phosphate is the phosphate salt of chloroquine, a quinoline compound with antimalarial and anti-inflammatory properties. Chloroquine is the most widely used drug against malaria, except for those cases caused by chloroquine resistant Plasmodium falciparum. Chloroquine Phosphate. Chloroquine is used to prevent or treat malaria caused by mosquito bites in countries where malaria is common. Malaria parasites can enter the body through these mosquito bites, and then live in body tissues such as red blood cells or the liver. This gene is imprinted, with preferential expression from the maternal allele. Mutations in this gene have been found in Wilms' tumor and lung cancer. This protein may act as a transporter of organic cations, and have a role in the transport of chloroquine and quinidine-related compounds in kidney.

    The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead.

    Synthesis of chloroquine phosphate

    Chloroquine drug Britannica, Chloroquine Phosphate - WebMD

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  3. Chloroquine is an anti-malaria medicine that works by interfering with the growth of parasites in the red blood cells of the human body. Parasites that cause malaria typically enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America, and Southern Asia.

    • Chloroquine Uses, Side Effects & Warnings -.
    • Chloroquine Sigma-Aldrich.
    • Chloroquine - an overview ScienceDirect Topics.

    Structure Activity Relationship of CHLOROQUINE. Addition of alpha diethylaminocresol in place of diethyl –diamino pentane results in production of amodiaquine, which is less toxics and also less effective as compared to chloroquine. Any substitution at position 1,2,5,6 will lead to decrease the pharmacological activity. Methodology TiII complex of chloroquine was synthesized by the reaction of chloroquine phosphate with titaniumIV oxide. The metal complex was characterized based on UV, IR and 1H NMR Spectroscopy. Chloroquine phosphate exhibits essentially no optical activity, existing as a racemic mixture. Chloroquine phosphate exists in two polymorphic forms giving rise to two melting ranges. Chloroquine phosphate is freely soluble in water—practically insoluble in alcohol, in chloroform and in ether.

     
  4. search-words Moderator

    Hydroxychloroquine is widely used in the treatment of post-Lyme arthritis. PLAQUENIL hydroxychloroquine sulfate Label Compare Plaquenil vs Chloroquine - Plaquenil Hydroxychloroquine - Side Effects, Dosage.
     
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    Hydroxychloroquine Plaquenil and Hair Loss Is my. The Autoimmune Disease the Plaquenil is Used for is Causing Hair loss. Autoimmune disease can cause inflammation in the body and this type of inflammation itself can trigger hair loss in the form of a hair shedding or ‘telogen effluvium.’ When rheumatoid arthritis flares patients can shed hair. When lupus flares, patients can lose hair.

    Plaquenil Oral Uses, Side Effects, Interactions.
     
  6. Grand-Host User

    Hydroxychloroquine An old drug with new relevance. ABSTRACTHydroxychloroquine is an immunomodulatory drug that has been used for 60 years to treat malaria and autoimmune diseases such as systemic lupus erythematosus and inflammatory arthritis, and potential new uses and benefits continue to emerge. Toxicity concerns have been addressed with updated prescribing recommendations.

    Hydroxychloroquine - Wikipedia