Additionally, another exception occurred while executing the custom error page for the first exception. Applies to hydroxychloroquine: oral tablet Along with its needed effects, hydroxychloroquine (the active ingredient contained in Plaquenil) may cause some unwanted effects. Oct findings in plaquenil toxicity Hydroxychloroquine hydroxyzine interaxtion Download PDF. Drug-induced ocular side effects are back in the spotlight, thanks to the Academy’s revision of its recommendations on screening for retinal toxicity from chloroquine and its analogue hydroxychloroquine Plaquenil. 1 There are hundreds of drugs with potential retinal toxicity—so many that the National Registry of Drug-Induced Ocular Side Effects doesn’t stratify them by. Retinal screening service will be provided by STH Ophthalmology department As patients are started on hydroxychloroquine, they will have a baseline retinal screen usually at 3 months but certainly within 12 months of starting, organised by the specialist. The specialist will also arrange a follow up retinal screen after 5 years Initially retinal toxicity due to long-term use of chloroquine Aralen for malaria was reported in 1959 by Hobbs et al. 106 Currently, hydroxychloroquine sulphate Plaquenil is the quinoline agent of choice for the treatment of autoimmune diseases with a far lower incidence of adverse reactions. 107, 108 Hydroxychloroquine has been associated. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Although not all of these side effects may occur, if they do occur they may need medical attention. Hydroxychloroquine and retinal deposit Plaquenil hydroxychloroquine sulfate dose, indications., Hydroxychloroquine and Retinal Screening Hydroxychloroquine how it worksHydroxychloroquine and tanningChloroquine phosphate buy over the counterPlaquenil autoimmuneHydroxychloroquine side effects rash pictures Find information about common, infrequent and rare side effects of Plaquenil Oral. Common and Rare Side Effects for Plaquenil Oral. Ocular side effects of anti-rheumatic medications what a.. Hydroxychloroquine toxicity - EyeWiki. This article is from June 2011 and may contain outdated material. Download PDF. Many systemic medications may cause retinal toxicity. One such commonly used medication for dermatologic and rheumatologic inflammatory conditions is hydroxychloroquine Plaquenil, a chloroquine derivative. The deposits affect the outer retina, photoreceptor layer, and the RPE, but preserve the inner retina. Prevalence. Although hydroxychloroquine retinal toxicity is thought to be rare, recent studies suggest it may have a higher prevalence than previously recognized. A large study examining patients with more than 5 years of HCQ use were. Chloroquine and hydroxychloroquine bind to melanin in the retinal pigment epithelium RPE and cause damage to the macular cones outside of the fovea. The drugs inhibit RPE lysosome activity, reduce phagocytosis of shed photoreceptor outer segments causing an accumulation of outer receptor segments.