The reaction can be phototoxic and/or photoallergic. Phototoxic reactions result from direct damage to tissue caused by light activation of the photosensitising agent, whilst photoallergic reactions are a cell-mediated immune response in which the is the light-activated photosensitising agent. Spilled water on plaquenil Chloroquine phosphate and alcohol Ra treatment plaquenil methotrexate Plaqunil rash. Support Forums Lupus New Topic Reply. Plaquenil has beneficial effects on 3 major aspects of lupus; skin rashes, aches & pains and fatigue. It has also been found to help in a number of other features of the disease, though less predictably. It is very effective in the treatment of a whole variety of lupus skin rashes. Once we determined that Plaquenil was worsening my psorasis to affect my nails and tendon inserts, I came off it for good. Skin rashes occasionally develop and hydroxychloroquine may make you more sensitive to the sun, so it is advisable to use the usual precautions of sunscreens and a hat if you are in the sun. The malaria medication hydroxychloroquine Plaquenil may ease the symptoms of some types of sun allergies. Therapy. If you have a severe sun allergy, your doctor might suggest gradually getting your skin used to sunlight each spring. Although some oral photosensitising medications can cause photoallergic reactions, most cause phototoxic reactions. Photoallergic reactions occur less commonly than phototoxic reactions and are mostly caused by photosensitising topical agents. Plaquenil and photosensitivity Sensitivity to UV light during treatment with chloroquine., Plaquenil and the sun - Sarcoidosis - Inspire Hydroxychloroquine sulfate and sun exposureDose of plaquenil for sarcoid skin lesionsIs prednisone and plaquenil safe during pregnancy View detailed reports from patients taking Hydroxychloroquine Sulfate who experienced photosensitivity reaction. Reports are from official medical reports as well as online extractions from user reviews and forum discussions. Hydroxychloroquine Sulfate Photosensitivity Reaction.. Sun allergy - Diagnosis and treatment - Mayo Clinic. Plaquenil Hydroxychloroquine - Side Effects, Dosage.. Plaquenil can improve photosensitivity. However imuran and other immunosuppressants, which I also take can worsen it. However imuran and other immunosuppressants, which I also take can worsen it. Thankfully for me that didn't happen and I still have a huge improvement on what I was like before where I would break out in a severe hive or blister like rash anywhere that was exposed. If photosensitivity is a problem for you, here are some ways to protect yourself from the sun Be Sun Smart With Lupus. If you are photosensitive, the best rule is to avoid midday and tropical sun. Lupus patients have to stay out of the sun -the sensitivity and my rashes, lupus body flares increased drastically if I am in the sun. We are instructed to wear sunscreen underneath our clothing – you can use RIT -Sun Guard to wash your clothes and it gives it a 30 SPF for about 20 washes.