I know its a supposed small risk, but thanks to Google I've uncovered some horror stories about vision issues after just 8mo-1yr and people swearing it is actually not uncommon. I've had the worst flare of my life over late summer, I've had 3 early miscarriages in 1.5 years, I'm almost always in some type of achy state or dead tired. Potential side effects and very real risks make the medication seem ridiculously dangerous. I'm not as familiar with MCTD but what I do know is that is can be just as dangerous as SLE. Is the vision loss something that will stop if the medication is stopped? Plaquenil and night sweats Chloroquine phosphate where to buy How long does Plaquenil take to work? Plaquenil works very slowly. In 1 to 3 months you should start to feel better. You may continue to get better for up to 1 year. Most people who take Plaquenil also take other medicines for pain and stiffness. How does Plaquenil work? Plaquenil changes the way your immune system works. Plaquenil is a slow-acting drug, meaning that it can take up to 6 months to experience the full benefits of this medication, but it is possible for symptoms to improve in as few as 1 or 2 months. Plaquenil and other antimalarials are the key to controlling lupus long-term, and some lupus patients may be on Plaquenil for the rest of their lives. To treat malaria Plaquenil is usually given for 3 days, starting with one high dose followed by a smaller dose during the next 2 days in a row. Take Plaquenil for the full prescribed length of time for malaria. Your symptoms may improve before the infection is completely cleared. Use protective clothing. Your external symptoms are a sign that something very wrong is going on inside you. Why in the world would anyone choose to poison themselves? You have a choice to make between letting your disease run rampant and continue to damage your body until it can no longer fight back or using one of the few weapons you have at your disposal to slow it down. Unfortunately, you have to roll the dice and decide which risk you'd rather take. How long is plaquenil good How effective is Plaquenil for Fibromyalgia by duration., Plaquenil What You Need to Know - Kaleidoscope Fighting Lupus Plaquenil time to take effect Plaquenil takes quite a long time to get to its peak effectiveness depending on what you read, anywhere from 3 months to a year. Unless you are having significant side effects, try to give it at least 6 months before you decide it doesn't work for you. PLAQUENIL" Rheumatoid Arthritis Community - Support Group. Plaquenil Uses, Dosage & Side Effects -. Plaquenil.long do I have to wait? DailyStrength. Plaquenil is NOT known to start working that fast. It takes anywhere from 4-6 months before the affects of Plaquenil are seen/felt. This is the case with everyone I know that takes it. It is recommended to be taken with food. Symptoms can start to improve in one to two months, but it may take up to six months before the full benefits of this medication are experienced. I'm back on it and waiting the 3-4 months it takes to work at least that's how long it took the first time. I have a great opthamologist who has assured me he will catch retinal damage before I will ever notice a change in my vision, so as far as I'm concerned, I want to stay on Plaquenil until I'm forced off it.