Yesterday my rheumatologist started me on hydroxychloroquine as well. Is anyone else on this combination and have you had any problems with it as I know hydroxychloroquine can cause eye sight problems. Price check on hydroxychloroquine Salisbury nc opthamologist plaquenil exams What was hydroxychloroquine originally used for Plaquenil hydroxychloroquine is an effective medication for autoimmune conditions and malaria that comes with less side effects than other DMARDs. Otrexup methotrexate is the first-choice treatment for many types of cancer and arthritis, but it has many side effects. The AUC of HCQ showed no significant difference p = 0.957 between any of the dosing occasions. CONCLUSION These results may explain the increased potency of the MTX-HCQ combination over MTX as a single agent and also the sustained effects of MTX when administered with HCQ. I was diagnosed with RA in march and have been on increasing dose of methotrexate. Yesterday my rheumatologist started me on hydroxychloroquine as well. Is anyone else on this combination and have you had any problems with it as I know hydroxychloroquine can cause eye sight problems. Thanks Recently my eyes have felt sore and, after posting a question on this site, I am seeing my GP on Monday. Thanks Hi Catjones I have been taking this combination, started on both of them in January this year. Difference between methotrexate and plaquenil Methotrexate and plaquenil -, Combination therapy with methotrexate and. Hla-dr4 rheumatoid arthritis and hydroxychloroquineItching plaquenilBlood monitoring hydroxychloroquinePlaquenil and atenolol Hydroxychloroquine is a disease-modifying anti-rheumatic drug DMARD. It regulates the activity of the immune system, which may be overactive in some conditions. Hydroxychloroquine can modify the underlying disease process, rather than simply treating the symptoms. Hydroxychloroquine Side-effects, uses, time to work. Does anyone take methotrexate and hydroxychloroquine. - NRAS. Methotrexate vs Plaquenil Comparison -. Hello thanks for your time. I started both of these ten weeks ago, I'm on 400mg hydroxy and 25mg of methotrexate. Last week I got in such a state about having to take them and it's got to a point where I constantly feel sick because I'm so anxious of having them, so I've been taken off hydroxychloroquine for two weeks so that now I only have medication on a Monday, I thought this would help. The difference was not significant P = 0.1. The mean standard deviation SD age of participants was 44.9 11.1 years in methotrexate group and 40.8 11.7 years in hydroxychloroquine group P = 0.4. The mean age of disease diagnosis was 42.3 12.8 and 37.6 11 years in methotrexate and hydroxychloroquine groups, receptively P = 0.3. Rheumatoid arthritis is a common disease 1 that causes substantial morbidity in most patients 2 and premature mortality in many. 2-4 Conventional therapy for rheumatoid arthritis includes the administration of antiinflammatory drugs, followed by disease-modifying antirheumatic drugs such as methotrexate, hydroxychloroquine.