Yesterday my rheumatologist started me on hydroxychloroquine as well. Is anyone else on this combination and have you had any problems with it as I know hydroxychloroquine can cause eye sight problems. Can plaquenil ever be stopped abruptly Plaquenil psoriasis Plaquenil safe dosage for eye With Plaquenil, the possibility of permanent vision damage scares me. I also want to be sure that I'm taking a drug that will slow/stop the progression of the disease. I've read elsewhere that Plaquenil is not as strong/effective in the treatment of early RA. With Methotrexate, the reports of nausea and possible liver damage are concerning. I have been diagnosed with Limited Scleroderma. My choices are Methotrexate, Plaquenil or Sulfasalzine Azulfidine. I researched them and determined Plaquenil would be my last choice, although it was his first, because I already have lattice degeneration of the retina in both eyes and one of the potential side effects is retinal problems. I was diagnosed with RA in march and have been on increasing dose of methotrexate. Yesterday my rheumatologist started me on hydroxychloroquine as well. Is anyone else on this combination and have you had any problems with it as I know hydroxychloroquine can cause eye sight problems. Thanks Recently my eyes have felt sore and, after posting a question on this site, I am seeing my GP on Monday. Thanks Hi Catjones I have been taking this combination, started on both of them in January this year. Methotrexate or plaquenil Perioperative Management of Medications Used in the Treatment., Methotrexate, Plaquenil or Sulfasalazine Azulfidine. Alternatives for hydroxychloroquine plaquenil The study is based on hydroxychloroquine sulfate and methotrexate sodium the active ingredients of Plaquenil and Methotrexate, respectively. Other drugs that have the same active ingredients e.g. generic drugs or brand names are also considered. Plaquenil vs. Methotrexate side effect and effectiveness.. Does anyone take methotrexate and hydroxychloroquine. - NRAS. Perioperative Management of Medications Used in the.. Plaquenil hydroxychloroquine is an effective medication for autoimmune conditions and malaria that comes with less side effects than other DMARDs. Otrexup methotrexate is the first-choice treatment for many types of cancer and arthritis, but it has many side effects. Mar 21, 2014 Ok, here is a question that we all could probably use an answer to; Methotrexate or Plaquenil for CREST Scleroderma. I have read Plaquenil is better for Lupus but Methotrexate is better for Scleroderma. Doctor said either is fine, but she wants me to choose. What is your experience with either or both. I need reviews. Compare Methotrexate vs Plaquenil head-to-head with other drugs for uses, ratings, cost, side effects, interactions and more. Methotrexate rated 6.7/10 vs Plaquenil rated 6.8/10 in overall patient satisfaction.