It may have both an anti-spirochaete activity and an anti-inflammatory activity, similar to the treatment of rheumatoid arthritis. And caution is required if patients have certain heart conditions, diabetes, psoriasis etc. Does plaquenil raise your blood pressure Hydroxychloroquine prescribing information Is plaquenil safe during pregnancy Hydroxychloroquine in breastfeeding To reduce the incidence of chloroquine and hydroxychloroquine toxicity, health care providers HCP's that prescribe these medications and those that screen for ocular toxicity have developed clear dosing and screening protocols that have reduced the risk of end-stage disease; bull's eye maculopathy and central vision loss Level I. Mar 17, 2019 Hydroxychloroquine is used to treat the symptoms of rheumatoid arthritis and systemic lupus erythematosus and to prevent and treat malaria. Includes hydroxychloroquine side effects, interactions and indications. Chloroquine and hydroxychloroquine can cause toxic retinopathy due to their binding of melanin in the retinal pigmented epithelium RPE as well as direct toxicity to retinal ganglion cells. Early findings include mottling of the RPE and blunted foveal reflex. As the retinopathy progresses, a bull's-eye maculopathy develops, as seen in these photos. The most serious adverse effects affect the eye, with dose-related retinopathy as a concern even after hydroxychloroquine use is discontinued. The most common adverse effects are a mild nausea and occasional stomach cramps with mild diarrhea. Hydroxychloroquine maculopathy Hydroxychloroquine Plaquenil Toxicity and Recommendations., Hydroxychloroquine Uses, Dosage & Side Effects - Chloroquine pills given to troops in viet name May 02, 2018 A study of about 200 patients with a history of hydroxychloroquine retinopathy, including 36 Asian patients, found that the pericentral pattern occurred in half the Asian patients but only 2% of the white patients. 31 The mechanism for this finding is unclear, but because pericentral retinopathy spares the macula, it can be missed using standard screening methods. Hydroxychloroquine An old drug with new relevance.. Bull's-eye maculopathy due to hydroxychloroquine toxicity. Plaquenil Side Effects on Your Eyes and Vision. Jan 05, 2020 Hydroxychloroquine maculopathy shares characteristic with several acquired or congenital diseases of the macula. The differential diagnosis includes age-related macular degeneration, cone dystrophy, rod and cone dystrophy, Stargardt’s disease, neuronal ceroid lipofuscinosis, and fenestrated sheen macular dystophy 1. Plaquenil hydroxychloroquine sulfate, Sanofi-Aventis and the less-used chloroquine are antimalarial drugs with anti-inflammatory properties that are used for the management of a spectrum of inflammatory conditions. Discussion. A risk factor for Plaquenil hydroxychloroquine retinotoxicity is a daily dose that exceeds 5.0 mg of drug per kg of body weight. The tool on the right simply calculates this threshold based on a patient’s real body weight. It’s important to understand that the daily dose is only one risk factor for plaquenil retinotoxicity.