This information should not take the place of medical care and advice from your healthcare providers. Hydroxychloroquine is a medication used to prevent and treat malaria and to treat autoimmune conditions such as rheumatoid arthritis or lupus. Hydroxychloroquine neck stiff neck pain Hydroxychloroquine medcication card There are no studies evaluating the safety and efficacy of chloroquine in during pregnancy. If you are pregnant this drug should be avoided unless it is necessary and the benefit outweighs the risk. Pregnant women are advised to avoid travel to countries where there is elevated risk of contracting malaria. 2,3 For pregnant individuals who still choose to or must travel to malaria-endemic areas where there is chloroquine resistance, currently none of the available prophylactic drugs are recommended in early pregnancy. In the last, LC3 and P62 were also observed in normal human proliferative, secretory, and decidua tissues. In conclusion, endometrial autophagy may be essential for embryo implantation, and it may be associated with endometrial decidualization during early pregnancy. • Autophagy-related markers were significantly decreased at implantation site. For more information on rheumatoid arthritis or lupus in pregnancy please see the Mother To Baby fact sheet on those topics at: https://mothertobaby.org/fact-sheets/rheumatoid-arthritis/pdf or https://mothertobaby.org/fact-sheets/lupus-pregnancy/pdf/. Hydroxychloroquine is sold under several brand names, including Plaquenil®. Chloroquine in early pregnancy Update New Recommendations for Mefloquine Use in Pregnancy, Atovaquone-Proguanil Use in Early Pregnancy and the Risk. Plaquenil well tolerated Chloroquine, extensively used in pregnancy, is generally thought to be safe for mother and fetus at the therapeutically recommended dose.2 Treatment of Plasmodium falciparum malaria in pregnancy in Kenya3 and Tanzania 4 have indicated the drug to be safe, although with the problem of treatment failure because of parasite resistance. Antimalarial drugs and pregnancy safety, pharmacokinetics.. Endometrial autophagy is essential for embryo implantation.. Methotrexate and Pregnancy Is It Safe If You Have RA?. It does not appear to be safe during pregnancy. Hydroxychloroquine is in the antimalarial and 4-aminoquinoline families of medication. Hydroxychloroquine was approved for medical use in the United States in 1955. It appears to be safe for use during pregnancy. It works against the asexual form of malaria inside the red blood cell. Chloroquine was discovered in 1934 by Hans Andersag. It is available as a generic medication. Chloroquine has not been formally assigned to a pregnancy category by the FDA. There are no controlled data in human pregnancies. Congenital anomalies were reported in the offspring of one woman being treated with chloroquine 250 to 500 mg daily during pregnancy for SLE; however, chloroquine has been used in the prophylaxis and treatment of malaria during pregnancy without evidence of fetal harm.