Mechanism of action of chloroquine in malaria treatment

Discussion in 'Hydroxychloroquine Sulfate' started by Fantaa, 28-Feb-2020.

  1. TSM XenForo Moderator

    Mechanism of action of chloroquine in malaria treatment


    License: CC BY 2.5Treatment of malaria is aimed at killing the schizonts by one or more mechanisms. Resistance occurs when the parasite develops mechanisms that reduce the effects of the antimalarials or bypasses the mechanisms of the drug.

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    Chloroquine acts exclusively in the erythrocyte stage of malaria parasites. The antimalarial mechanism of action from chloroquine has not been fully elucidated. Many theories have been developed to elucidate the chloroquine mechanism of action, including DNA binding and inhibition of various enzymes and/or transporters. Mechanism of action As with chloroquine, quinine interferes with heme polymerization. Clinical uses. Multidrug-resistant malaria treatment; Severe malaria, including cerebral malaria intravenous quinine is the drug of choice. Mechanism of Action Chloroquine, a 4-aminoquinoline, is an anti-protozoal agent. The precise mechanism by which Chloroquine exhibits activity is not known. Chloroquine, may exert its effect against Plasmodium species by concentrating in the acid vesicles of the parasite and by inhibiting polymerization of heme. It can also inhibit certain enzymes by its interaction with DNA.

    Monotherapy should be avoided to prevent drug considered a superior antimalarial drug to quinine. Effects of the antimalarial drug primaquine on the dynamic structure of lipid model membranes. The American journal of tropical medicine and hygiene, 77(6 Suppl), 29–35. Resistance is a major problem in some parts of the world, e.g., Africa and Southeast Asia; therefore, newer drugs are utilized.

    Mechanism of action of chloroquine in malaria treatment

    Treatment_of_malaria TUSOM Pharmwiki, Antimalarial Drugs – Quinine, Quinidine, Sulfonamides & more

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  6. Chloroquine is a 4-aminoquinolone compound with a complicated and still unclear mechanism of action. It is believed to reach high concentrations in the vacuoles of the parasite, which, due to its alkaline nature, raises the internal pH.

    • Antimalarial medication - Wikipedia.
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    For treatment of malaria Adults—At first, 1000 milligrams mg once a day. Then, 500 mg 6 to 8 hours after the first dose, and 500 mg on the second and third days of treatment. Adults with low body weight and children—Dose is based on body weight and must be determined by your doctor. Although these drugs are known to accumulate by a weak base mechanism in the acidic food vacuoles of intraerythrocytic trophozoites and thereby prevent hemoglobin degradation from occurring in that organelle, the mechanism by which their selective toxicity for lysosomes of malaria trophozoites is achieved has been subject to much discussion and argument. Chloroquine is thought to exert its antimalarial effect by preventing the polymerization of toxic heme released during proteolysis of hemoglobin in the Plasmodium digestive vacuole. The mechanism of this blockade has not been established.

     
  7. space_friend New Member

    Hydroxychloroquine is widely used in the treatment of post-Lyme arthritis. Methotrexate and plaquenil - @Kristinsaba1988 - Scleroderma. Plaquenil hydroxychloroquine 200mg is it causing itchy skin. Plaquenil and skin DailyStrength
     
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    JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Facial Plastic Surgery JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959)Kinetic visual field testing in patient 1 demonstrating progressive constriction of the visual fields of both eyes, from 3 months following cessation of chloroquine phosphate (A) to review 5 years later (B). Risk Factors for Hydroxychloroquine and Chloroquine. Retinal toxicity associated with chronic exposure to. Plaquenil Risk Calculators
     
  9. Lesha-narhoz Well-Known Member

    Plaquenil Hydroxychloroquine - Side Effects, Dosage. Plaquenil comes in 200 milligram mg tablets that are taken by mouth. To prevent malaria in adults, two tablets are typically taken once a week, on the same day each week.

    Hydroxychloroquine Información Española De la Droga