What is the mode of action of chloroquine

Discussion in 'Hydroxychloroquine Sulfate' started by Trex, 08-Mar-2020.

  1. LYSI New Member

    What is the mode of action of chloroquine


    Parasites that cause malaria typically enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America, and Southern Asia.

    Hydroxychloroquine blood monitoring Plaquenil associated hyperpigmentation

    It is caused by protozoan parasites belonging to the Plasmodium genus and transmitted by an infected female Anopheles mosquito. This disease affects mainly children aged less than 5 years. Among the four species of malarial parasite which infect humans. Mechanism of Action Chloroquine, a 4-aminoquinoline, is an anti-protozoal agent. The precise mechanism by which Chloroquine exhibits activity is not known. Chloroquine, may exert its effect against Plasmodium species by concentrating in the acid vesicles of the parasite and by inhibiting polymerization of heme. It can also inhibit certain enzymes by its interaction with DNA. Its mechanism of action is unknown; however, malarial parasites invade human red blood cells, and chloroquine may prevent malarial parasites from breaking down metabolizing hemoglobin in human red blood cells.

    Chloroquine is also used to treat amebiasis (infection caused by amoebae). Chloroquine is used to treat and to prevent malaria.

    What is the mode of action of chloroquine

    Chloroquine and hydroxychloroquine – Knowledge for medical students and., Chloroquine - FDA prescribing information, side effects.

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  4. Oct 01, 2018 Mechanism of Action Chloroquine, a 4-aminoquinoline, is an anti-protozoal agent. The precise mechanism by which Chloroquine exhibits activity is not known. Chloroquine, may exert its effect against Plasmodium species by concentrating in the acid vesicles of the parasite and by inhibiting polymerization of heme. It can also inhibit certain enzymes by its interaction with DNA.

    • Chloroquine - FDA prescribing information, side effects and uses.
    • Aralen chloroquine Malaria Drug Side Effects & Dosage.
    • COVID-19 - EMCrit Project.

    Mechanism of Action Chloroquine is an antimalarial agent. While the drug can inhibit certain enzymes, its effect is believed to result, at least in part, from its interaction with DNA. Mechanism of action of chloroquine. Entry into the parasitized RBCs; 1. Accumulation in food vacuole of the parasite- role of pH gradient chloroquine trapping Affects asexual cycle of plasmodium specie. Once administered, it has to enter site of action. It rapidly enters and gets concentrated in food vacuole, present within erythrocytes. Antimalarial mode of action and resistance. Chloroquine acts exclusively in the erythrocyte stage of malaria parasites. The antimalarial mechanism of action from chloroquine has not been fully elucidated. Many theories have been developed to elucidate the chloroquine mechanism of action, including DNA binding and inhibition of various enzymes and/or transporters.

     
  5. IGRA New Member

    Plaquenil is the brand name for the prescription drug hydroxychloroquine. Stomach cramps from Plaquenil - what to do? Lupus Forums at The Lupus. Upset stomach from plaquenil - Sjogren's World Plaquenil What You Need to Know - Kaleidoscope Fighting Lupus
     
  6. waterfall User

    Chloroquine has long been used in the treatment or prevention of malaria from Plasmodium vivax, P. malariae, excluding the malaria parasite Plasmodium falciparum, for it started to develop widespread resistance to it. Chloroquine Oral Uses, Side Effects, Interactions. Chloroquine Indications, Side Effects, Warnings - Chloroquine DermNet NZ
     
  7. romiz Well-Known Member

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  8. Janis Well-Known Member

    Chloroquine and Proguanil - Superdrug Health Clinic Chloroquine and proguanil is available as an over the counter medicine from your pharmacy, so you don’t need to see a doctor for a prescription in order to be able to buy it. However, it is important that you make sure that it will protect you from the malaria parasites endemic to the region you are travelling to.

    Chloroquine/Proguanil Price Comparison Uses, Dosage, Form.