It regulates the activity of the immune system, which may be overactive in some conditions. Hydroxychloroquine can modify the underlying disease process, rather than simply treating the symptoms. Is hydroxychloroquine a time release pill Dose of chloroquine at 4 0 year When plaquenil doesn t work For children, sulfasalazine should only be started by a specialist. Sulfasalazine won’t start to work immediately, and it could be at least 12 weeks before you notice any effects. You shouldn’t take sulfasalazine if you’re known to have an allergy to salicylates. Salicylate is a natural chemical that is found in some foods. If the plaquenil is helping and they say you need it, I'd take it - the side effects will go away. I've not had experience with sulfasalazine - but from what I've read, the side effects of that med are about the same as those of plaquenil. BTW - sulfasalazine is an anti-inflammatory. I was very gassy when starting out. It took me 6 weeks to go from 500mg per day to 2000mg. My symptoms were pretty severe in July 2018, and it took about 4 months for Plaquenil to do anything. At about 6 weeks on sulfasalazine, I started getting improvements. I'm now at 9 weeks and I went all day and barely had any joint pain. Hydroxychloroquine is often taken in combination with other drugs such as methotrexate. Over the long term hydroxychloroquine can reduce pain, swelling and joint stiffness. It may be as long as 12 weeks before you notice the benefits. What to use when plaquenil and sulfasalazine doesn't work Combination hydroxychloroquine and sulfasalazine - HealthUnlocked, Plaquenil and sulfasalazine - Autoimmune Disorders - MedHelp How quickly does plaquenil work My mum was started on sulfasalazine 4 weeks ago for RA with severe bilateral hand pain and swelling. Initially everything was fine but when the dose was increased in the 2nd week to 500mg twice a day her mood started to deteriorate and developed symptoms of plantar fascitis. Sulfasalazine User Reviews for Rheumatoid Arthritis at. Sulfasalazine Reviews & Ratings at. What next if plaquenil doesn't work? -. You should not use hydroxychloroquine if you are allergic to it. Hydroxychloroquine should not be used for long-term treatment in children. To make sure this medicine is safe for you, tell your doctor if you have a history of vision changes or damage to your retina caused by an anti-malaria medication; I am a 72 year old female, diagnosed with RA 6 years ago. I took Plaquenil 200x2 from 2012-2016, along with Prednisone to start. Due to the fact, I could not use my hands because of the swelling, I risked the possible vision problems. By 2012, symptom free and still fearful of vision loss, I stopped the drug. Plaquenil hydroxychloroquine is an effective medication for autoimmune conditions and malaria that comes with less side effects than other DMARDs. Azulfidine Sulfasalazine is used to treat moderate to severe inflammatory bowel conditions. It's also used with other medicines to treat rheumatoid arthritis.