Moreover, it is used as an adjunct in chemotherapy, and it is being investigated as a treatment for diabetes and heart disease, thanks to its anti-inflammatory, lipid-lowering, and antithrombotic properties. But as ophthalmologists know, excessive HCQ dosages can result in toxic damage to the eye. Visual field changes with plaquenil Plaquenil drug card Chloroquine pic Nov 02, 2018 Rosenbaum discussed the guidelines from the American Academy of Ophthalmology AAO published in Ophthalmology. He reviewed the data which supports the use of the guidelines daily dose 5 mg/kg of actual body weight; a baseline eye exam; and eye exams at 5 years and annually thereafter. The most recent 2016 guidelines from the American Academy of Ophthalmology AAO recommend the dose of HCQ ≤5 mg/kg real body weight to minimize toxicity 1. According to these new guidelines, the risk of HCQ retinal toxicity is less than 1 % in the first year of therapy and less than 2 % up to 10 years of therapy. Background/Purpose Hydroxychloroquine HCQ is a widely-used medication in many rheumatologic conditions. The most worrisome toxicity is irreversible damage to retinal pigment epithelium which can lead to blindness. The most recent 2016 guidelines from the American Academy of Ophthalmology AAO recommend the dose of HCQ ≤5 mg/kg real body weight to minimize toxicity1. According to these Highlights of the 2016 guidelines include the following. “The bottom line is that the daily dose should be 5.0 mg per kg or less, using real body weight,” said Michael F. In an effort to reduce the incidence of HCQ retinopathy, the Academy published screening guidelines in 2002. Here’s an overview of the latest guidelines—and troubling evidence that far too many patients are still receiving too high a dose of HCQ (see “Excessive Dosing Still a Problem,” below). Hydroxychloroquine dose aao New App to Tackle Hydroxychloroquine Dosing Dilemma., New Guidelines on Hydroxychloroquine Dosage - Where Are We. Can you take hydroxychloroquine sulfate if youre allergic to.sulfaPlaquenil revised dosingSides effects of hydroxychloroquinePlaquenil and rapid heartbeat Jan 05, 2020 Hydroxychloroquine retinopathy is most influenced by daily dose and duration of use. Risk for toxicity is less with 5.0 mg/kg real weight/day for hydroxychloroquine and 2.3 mg/kg real weight/day for chloroquine. Patients are at low risk during the first 5 years of treatment. Hydroxychloroquine toxicity - EyeWiki. New Guidelines on Hydroxychloroquine Dosage - Where Are We? - ACR.. New App to Tackle Hydroxychloroquine Dosing Dilemma - American Academy.. Irreversible retinal damage observed in some patients who had received hydroxychloroquine sulfate; significant risk factors for retinal damage include daily doses of hydroxychloroquine sulfate greater than 6.5 mg/kg 5 mg/kg base of actual body weight, durations of use greater than five years, subnormal glomerular filtration. Oct 30, 2019 Based on these risks, the American Academy of Ophthalmology AAO recommends not exceeding a daily hydroxychloroquine dosage of 5 mg/kg using actual body weight in most patients. Previous recommendations to use ideal body weight are no longer advised; very thin patients in particular were at increased risk for retinal toxicity using this practice. The current maximum daily HCQ dose recommended by the AAO is 5 mg/kg of real weight. The 2011 guidelines suggested a maximum dose of 6.5 mg/kg of ideal weight.