Chloroquine epilepsy

Discussion in 'Northwest Pharmaceuticals Canada' started by coolann, 05-Mar-2020.

  1. azoff Moderator

    Chloroquine epilepsy


    Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it.

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    Chloroquine is the generic form of the brand-name prescription medicine Aralen, which is used to prevent and treat malaria — a mosquito-borne disease caused by a parasite — and to treat. Three cases are reported of patients developing seizures whilst taking chloroquine. Recently, eight such cases have been reported elsewhere. A review of all patients described in the literature is given. Possible relationships between chloroquine and the occurrence of seizures are discussed and further studies recommended. Chloroquine may increase cyclosporine blood levels. Cyclosporine blood levels should be monitored and, if necessary, chloroquine should be stopped. Combining chloroquine and mefloquine may increase the risk of seizures. Chloroquine can reduce the antibody response to primary immunization with intradermal human diploid-cell rabies vaccine.

    The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead.

    Chloroquine epilepsy

    Chloroquine Oral Route Before Using - Mayo Clinic, Does chloroquine cause seizures? Presentation of three new.

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  6. Four cases of seizures were associated with therapeutic doses of chloroquine phosphate. This is, to our knowledge, the first specific report of this side effect in the literature. Other serious side effects have been noted, especially those involving the central and peripheral nervous systems. It is.

    • Chloroquine Seizures Report of Four Cases JAMA JAMA Network.
    • Aralen chloroquine Malaria Drug Side Effects & Dosage.
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    Epilepsy, history of—May increase risk for seizures. Glucose-6-phosphate dehydrogenase G6PD deficiency—May cause hemolytic anemia in patients with this condition. Kidney disease or; Liver disease—Use with caution. The effects may be increased because of the slower removal of chloroquine from the body. Patients with history of epilepsy should be advised about the risk of chloroquine provoking seizures. Drug Interactions. Antacids and kaolin Antacids and kaolin can reduce absorption of chloroquine; an interval of at least 4 hours between intake of these agents and chloroquine should be observed. Doses expressed as chloroquine base. Each tablet contains 155 mg of chloroquine base equivalent to 250 mg of chloroquine phosphate. Syrup contains 50 mg/5 mL of chloroquine base equivalent to 80 mg/5 mL of chloroquine phosphate.

     
  7. mikulchina Guest

    Haemozoin is a disposal product formed from the digestion of blood by some blood-feeding parasites. Inhibition by chloroquine of a novel haem polymerase enzyme activity in. Heme polymerase Modulation by chloroquine treatment of a rodent. Chloroquine - My Cancer Genome
     
  8. mr_bobbin New Member

    Saltcorner Article New Approach to Treating Marine Ich and other. It now appears these medications can be considered ‘outdated’ and our fish treated quite successfully in either fish-only or reef aquariums with an alternative product, with no harm to filtration bacterium! This product is called ‘Chloroquine phosphate’ or Aralen®.

    Seachem - ParaGuard