Hydroxychloroquine overdose toxicokinetics and management

Discussion in 'Trusted Online Pharmacy' started by Ectaco, 11-Mar-2020.

  1. valery_k Moderator

    Hydroxychloroquine overdose toxicokinetics and management


    One such commonly used medication for dermatologic and rheumatologic inflammatory conditions is hydroxychloroquine (Plaquenil), a chloroquine derivative. It is used to treat many diseases including malaria, rheumatoid arthritis and systemic lupus erythematosus.

    What r the side effects of plaquenil Plaquenil et douleurs articulaires Hydroxychloroquine bluelight Literature review of chloroquine syrup

    Jan 05, 2020 Hydroxychloroquine Plaquenil and chloroquine cause ocular toxicity to various parts of the eye such as the cornea, ciliary body, and retina. Chloroquine can also induce cataract formation; however, no reports of hydroxychloroquine and cataract have been reported 1. Background The management and toxicokinetics of hydroxychloroquine overdose are poorly described. Case Report We report a case of an 18-year-old girl who ingested 20 g of hydroxychloroquine. She developed marked hypokalemia, hypotension, and ventricular tachyarrhythmias but survived with treatment including intubation, adrenaline infusion, high-dose diazepam, and aggressive potassium replacement. Mechanism of Toxicity. The mechanism of hydroxychloroquine retinal toxicity has yet to be fully elucidated. Studies have shown that the drug affects the metabolism of retinal cells and also binds to melanin in the RPE, which could explain the persistent toxicity after discontinuation of the medication.

    It is imperative that patients and physicians are aware of and watch for this drug’s ocular side effects. Retinal toxicity from hydroxychloroquine is rare, but even if the medication is discontinued, vision loss may be irreversible and may continue to progress.

    Hydroxychloroquine overdose toxicokinetics and management

    Hydroxychloroquine overdose toxicokinetics and management., Hydroxychloroquine Overdose Toxicokinetics and Management.

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  6. Hydroxychloroquine Plaquenil is an aminoquinoline derivative, closely related to chloroquine, that is used in the treatment of malaria, lupus erythematosus and rheumatoid arthritis. It is available as the sulfate salt

    • Hydroxychloroquine - Biomedical Publications.
    • Hydroxychloroquine-Induced Retinal Toxicity - American..
    • Chloroquine and Hydroxychloroquine Toxicity Treatment..

    Hydroxychloroquine is synthesised by adding a hydroxyl group to an N-ethyl group of chloroquine rendering it 2-4 times less toxic. 1 As hydroxychloroquine and chloroquine share similar structural and pharmacological properties, and there is relatively richer experience with chloroquine toxicity, most of the following discussions are based on studies of Find patient medical information for Hydroxychloroquine Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Toxicokinetics Both chloroquine and hydroxychloroquine have excellent oral absorption and bioavailability. Both have a long and variable plasma elimination half-life because of a high volume of distribution, an extended mean residence time HCQ 1300 hours and CQ 900 hours and with about half the drug metabolites undergoing unmodified renal clearance.

     
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    Plaquenil (hydroxychloroquine) belongs to a group of medicines called quinolines. Plaquenil Hydroxychloroquine - Side Effects, Dosage. Will you have Sleep disorder with Plaquenil - eHealthMe Plaquenil and Sleep - Sjogren's World
     
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    Prednisone and Plaquenil drug interactions - eHealthMe Summary Drug interactions are reported among people who take Prednisone and Plaquenil together. This study is created by eHealthMe based on reports of 13,794 people who take Prednisone and Plaquenil from Food and Drug Administration FDA, and is updated regularly.

    Plaquenil What You Need to Know - Kaleidoscope Fighting Lupus
     
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    Syndrome de Sjögren enfin une nouvelle approche de traitement - Revue. C’est dans ce contexte morose qu’ont émergé les thérapies biologiques, qui ouvrent de nouvelles perspectives de traitement. Dans cet article, nous allons tout d’abord résumer l’approche symptomatique du traitement du SS notamment pour ce qui concerne le syndrome sec et les manifestations systémiques.

    Gougerot-Sjögren syndrome de SNFMI