Hydroxychloroquine corneal verticillata

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  1. bullhead New Member

    Hydroxychloroquine corneal verticillata


    She suffered from Sjogren syndrome and inflammatory arthritis and was currently treated with prednisone and methotrexate. She was previously treated with hydroxychloroquine (Plaquenil) 200mg bid (6.5mg/kg) for 10 years, which was stopped one year prior to presentation.

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    Sep 13, 2019 Note This document contains side effect information about hydroxychloroquine. Some of the dosage forms listed on this page may not apply to the brand name Plaquenil. For the Consumer. Applies to hydroxychloroquine oral tablet. Along with its needed effects, hydroxychloroquine the active ingredient contained in Plaquenil may cause some. Cornea verticillata; Vertex keratopathy Chloroquine toxicity is characterized by whorl-like corneal epithelial deposits. Medications of the chloroquine family, including chloroquine Nivaquine. Corneal deposits called vortex keratopathy or corneal verticillata result from binding to cellular lipids and deposition of the drug in the basal epithelial layer of the cornea. Discontinuation of the drug usually causes the deposits to disappear over time.

    Review of systems: Blurred vision, halos, dry eye, dry mouth, gastroesophageal reflux, joint pain Pupils: Reactive to light in each eye from 5 mm in the dark to 2 mm in the light. Extraocular movements: Full, both eyes (OU) Confrontation visual fields: Full OU Intra-ocular pressure The optic nerves appeared healthy with a 0.3 cup-to-disc ratio. Past Ocular History: None Medical History: Sjogren syndrome and inflammatory arthritis, supraventricular tachycardia, anxiety, depression, peptic ulcer disease Medications: prednisone, methotrexate, amitriptyline, ranitidine, estradiol, tizanidine, diltiazem, Restasis Allergies: codeine, droperidol Family History: heart disease, arthritis, cancer Social History: occasional alcohol but no tobacco or intravenous drug use.

    Hydroxychloroquine corneal verticillata

    Drug-induced corneal epithelial changes - ScienceDirect, Chloroquine Toxicity, Cornea Verticillata SpringerLink

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  3. Hydroxychloroquine is still a safe and beneficial drug for use in rheumatic diseases. Corneal verticillata is less common with HCQ than CQ 7, 21, 22. Retinopathy. Although rare, retinopathy is the major concern expressed by most patients and clinicians using HCQ.

    • Hydroxychloroquine-related retinal toxicity Rheumatology..
    • Chloroquine And Hydroxychloroquine Toxicity - StatPearls - NCBI Bookshelf.
    • Cornea verticillata - Ophthalmology.

    Cornea verticillata, also called vortex keratopathy or whorl keratopathy, is a condition characterised by corneal deposits at the level of the basal epithelium forming a faint golden-brown whorl pattern. It is seen in Fabry disease or in case of prolonged amiodarone intake. Causes. Amiodarone Fabry’s disease Chloroquine Hydroxychloroquine Toxicity from hydroxychloroquine may be seen in two distinct areas of the eye the cornea and the macula. The cornea may become affected relatively commonly by an innocuous cornea verticillata or vortex keratopathy and is characterized by whorl-like corneal epithelial deposits. These changes bear no relationship to dosage and are usually. If cornea verticillata is associated with a drug that is known to produce retinal toxicities, most notably hydroxychloroquine, chloroquine, chlorpromazine, and tamoxifen, patients should be routinely monitored with automated visual fields plus spectral-domain optical coherence tomography SD OCT 20.

     
  4. cmaster Well-Known Member

    Applies to hydroxychloroquine: oral tablet Along with its needed effects, hydroxychloroquine may cause some unwanted effects. Plaquenil Tinnitus - The Tinnitus Blog Plaquenil Side Effects on Your Eyes and Vision Common Plaquenil side effects a study from FDA data - eHealthMe
     
  5. starOFF Guest

    CHLOROQUINE Drug BNF content published by NICE Chloroquine appears to be more retinotoxic than hydroxychloroquine. Screening recommendations for chloroquine All patients planning to be on long-term treatment should receive a baseline examination including fundus photography and spectral domain optical coherence tomography within 6-12 months of treatment initiation;

    Primaquine Side Effects Common, Severe, Long Term -