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    More than 500 Canadian men feel they weren’t warned properly about a prescription baldness medication they say has left them impotent, even years after they stopped taking it. case was approved by the province’s supreme court this month. Two class-action lawsuits, one in Ontario and one in British Columbia, have been filed against Merck Frosst Canada, makers of finasteride — the key ingredient used in Propecia, a hair loss drug, and Proscar, a prostate drug also used to treat baldness. Merck denies the claims and says it acted responsibly in all aspects of producing and marketing the drugs. The plaintiffs argue Merck failed to warn them of lasting sexual dysfunction after stopping treatment, despite the product’s labels in Europe indicating a risk of “persistent erectile dysfunction after discontinuation of treatment” as far back as 2008. While Canadian labels at the time listed sexual dysfunction as a rare side effect, they indicated it was resolved in men “who discontinued therapy.” A warning of persistent erectile dysfunction didn’t appear in Canada until November 2011.“If they were telling men in Europe about this, but not Canadian men, then the drug company was applying a double standard,” said David Klein, whose firm launched both cases. “Knowing (the full side-effects), would you risk it? I’d rather be bald and so would most men.”Sean Ramsaran, 26, was prescribed Propecia by his dermatologist in 2009 when he noticed his hair was thinning and now calls himself “a useless person.”Four years later, he wonders why neither Merck nor Health Canada warned him of the drug’s risks sooner.“I can’t get an erection no matter how I try,” said the Toronto resident, noting he quit the drug a year into treatment after his sex drive plummeted. I have nightmares, flashbacks to experiences I had while on the drug with my girlfriend, not being able to do anything.”Merck denies any failing in its monitoring of the drugs. “The company acted responsibly and appropriately with respect to Propecia and Proscar throughout the development, marketing and post-marketing monitoring of these medicines,” wrote spokeswoman Lainie Keller in an email. She added there is no scientific data showing the drugs cause persistent impotence after discontinuing use. Generic equivalents may also be supplied by alternate manufacturers. You can buy Propecia online through Canadian Pharmacy at huge savings. We do require a valid prescription from your doctor. Our Canadian Pharmacy carries brand and generic medications from Canada as well as other international pharmacies. For more information and further details, please call Customer Service at 1866-485-7979 or email us. The brand name Propecia comes from Canada, Turkey and New Zealand manufactured by Merck. The generic Finasteride comes from India (by Cipla called Finpecia) and Canada (by Auro Bingdo also called Auro-Finasteride or Sandoz).

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    Background: Being a selective estrogen receptor inhibitor (SERM) tamoxifen may be used an alternative to clomiphene citrate for ovulation induction in women with anovulatory infertility. Comparison of tamoxifen and clomiphene citrate for ovulation induction: a meta-analysis. This study was conducted to evaluate the safety and efficacy of tamoxifen as compared to clomiphene citrate in women with primary or secondary anovulatory infertility due to Polycystic Ovarian Syndrome (PCOS). Methods: One hundred women suffering from anovulatory infertility and attending the infertility clinic and were recruited for the study. Williamson JG and Ellis JD The induction of ovulation by tamoxifen. Patients were randomized to receive either clomiphene citrate (100-150 mg) or tamoxifen treatment (40-80 mg). Kettal LM, Roseff SJ, Berga S et al: Hypothalamic-pituitary-ovarian response to clomiphene citrate women with polycystic ovary syndrome. Brown J, Farquhar C, Beck J, Boothroyd C, Proctor M, Hughes E. Eden JA, Place J, Carter GD, Jones J, Alaghband-Zadeh, Pawson ME. Characteristics relating to ovarian risk: Collaborative analysis of 12 US case-control studies. The ovulation was monitored from day 5 to day 9 of menstrual cycle followed up by transvaginal ultrasound from day 11 every alternate day for 10 days. Results: The baseline characteristics of mean age, weight, proportion of patients with primary and secondary infertility and mean duration of infertility were comparable between both the study groups. Clark JH, Markaverich BM: The agonistic-antagonistic properties of clomiphene: A review. Oral anti-estrogen and medical adjuncts for subfertility associated with anovulation. The effect of clomiphene citrate on follicular phase increase in endometrial thickness and uterine volume. Out of 50 patients who received clomiphene citrate, 37 showed successful ovulation (ovulation rate of 64%) and 16 patients conceived (pregnancy rate of 32%). In tamoxifen group 41 women showed successful ovulation (ovulation rate of 82%) and 18 women conceived (pregnancy rate of 36%). Breast cancer patients worry about effects of tamoxifen on fertility. azithromycin antibiotic Tamoxifen citrate uses, action, side effects and dosage information Fertility Medications Tamoxifen Carolina Conceptions
     
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