The most common medications used to treat erectile dysfunction (ED) are Viagra, Cialis, Sildenafil, and Levitra. They belong to a class of drugs called phosphodiesterase 5 inhibitors (PDE5 inhibitors), which will be explained below. An erection occurs when someone is stimulated by an erotic thought or sexual contact. That leads to a series of chemical reactions in the blood vessels of the penis that results in 6 times the blood flow getting trapped in the penis. An erection might last indefinitely if it weren’t for chemicals called phosphodiesterases. They work at reversing the process that keeps the penis erect. Usually there is a balance between the chemicals that cause an erection and those that would return the penis to being flaccid. They pull in opposite directions with one dominating over the other in a perfect sequence that lets a man have an erection as long as it is needed. doxycycline grapefruit Sildenafil is a medicine used to treat erectile dysfunction. 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