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    Sildenafil citrate is a phosphodiesterase type 5 inhibitor. In countries worldwide, including Mexico, sildenafil citrate is approved for the treatment of erectile dysfunction as conventional film-coated tablets of 50-mg and 100-mg strengths for oral administration with water (Viagra®, Pfizer Inc, New York, NY). Viagra is rapidly absorbed, reaching a mean ) is approximately 4 hours [1]. The absolute average bioavailability after oral administration is about 41% [1,2]. For doubling the dose, across the range of 25–200 mg, a small and clinically insignificant degree of non-proportionality was observed in predicted increases in C (2.1- fold) and in area under the plasma concentration versus time curve (AUC, 2.2-fold) [1]. A chewable tablet formulation of sildenafil citrate has been developed that does not have to be swallowed whole. Because citrate salts have a bitter taste, taste masking was essential to improve the palatability of the chewable tablet formulation. inderal review * Chewable tablet differs in format, not effects * Study says around 6 million Mexican men impotent By Elinor Comlay MEXICO CITY, March 17 (Reuters) - Mexican men who have difficulty swallowing Viagra pills will soon have a chewable version of Pfizer Inc’s() impotence drug. pharmaceutical company said on Thursday that the chewable form of the 13-year-old pale blue pill was developed in response to studies of the Mexican market, which is Viagra’s biggest in Latin America after Brazil. Known as Viagra Jet, it was developed over four years in Mexico, where the company will start selling it on March 21. “It’s a new alternative for patients and doctors,” said Beatriz Romero, Pfizer’s marketing manager in Mexico. “The chewable format could appeal to patients, particularly those who can’t swallow the tablets.” Pfizer said studies have shown that as many as 60 percent of people grind tablets or open capsules to make the contents easier to ingest. About 6 million Mexican men suffer from impotence, according to a 2001 study published in the medical journal Revista Mexicana Urologia. Pfizer said it estimates that 1 million of them receive treatment. Pfizer said it sells 3 million Viagra tablets a year in Mexico. According to research firm IMS Health, Viagra has about one third of the market share in Latin America’s second biggest economy.

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